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Current status of research and application in vascular stents
  • ISSN号:1671-7856
  • 期刊名称:《中国比较医学杂志》
  • 时间:0
  • 分类:Q513[生物学—生物化学] TH77[机械工程—仪器科学与技术;机械工程—精密仪器及机械]
  • 作者机构:[1]Key Laboratory of Advanced Technology of Materials of Education Ministry, Southwest Jiaotong University, Chengdu 610031, China, [2]Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden 01097, Germany, [3]School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
  • 相关基金:This work was supported by the National Basic Research Program of China (2011CB606204) and the National Natural Science Foundation of China (81330031, 81271701).
中文摘要:

心血管的疾病是在现代社会的死亡的领先的原因。使用脉管的 stents 治疗这些冠、外部的动脉疾病是最有效、很快采用的医药干预之一。在脉管的 stents 的 25 年开发期间,象药 eluting stents 和 endothelial 祖先房间俘获一样的革命心血管的 stents stents 出现了。在这评论,脉管的 stents 的进化被总结,试图提供进脉管的 stents 的未来的一瞥。推进了图案,集中于新底层,新平台,新药和新 biomolecules 的调查当前在有有希望的临床的研究的评估下面。时间顺序的概念功能的 stent 在这篇论文被提起了。它在培植以后并且随后在第一个阶段介绍 anti-proliferative 性质支持 endothelialization。没有有毒的离子或有毒的降级产品的版本,它也显示出长期的不活泼。这个概念的成功简短在这模型 stents 与临床的研究被介绍。

英文摘要:

Cardiovascular diseases have been the leading cause of death in modern society. Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions. During the twenty-five years' development of vascular stents, revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged. In this review, the evolution of vascular stents is summarized, aiming to provide a glimpse into the future of vascular stents. Advanced designs, focusing on the investigations of new substrates, new platforms, new drugs and new biomolecules are currently under evaluation with promising clinical studies. The concept of "time sequence functional stent" has been raised in this paper. It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization. It also shows long-term inertness without release of toxic ions or toxic degradation products. The success of this concept is briefly presented with a clinical study in this model stents.

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期刊信息
  • 《中国比较医学杂志》
  • 北大核心期刊(2014版)
  • 主管单位:中国科学技术协会
  • 主办单位:中国实验动物学会 中国医学科学院医学实验动物研究所
  • 主编:秦川
  • 地址:北京市朝阳区潘家园南里5号
  • 邮编:100021
  • 邮箱:b67761337@126.com
  • 电话:010-67779337
  • 国际标准刊号:ISSN:1671-7856
  • 国内统一刊号:ISSN:11-4822/R
  • 邮发代号:82-917
  • 获奖情况:
  • 中国科技论文统计源期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),中国中国科技核心期刊,中国北大核心期刊(2014版)
  • 被引量:7696