中文摘要：

聚β-羟基丁酸酯（PHB）是一种具有良好的生物相容性和生物降解性能的热塑性聚酯，在环境降解材料、药物缓释等方面已有广泛的应用，但是由于其性脆，在熔点附近易分解，阻碍了其大规模工业应用．为了克服PHB的这些缺点，很多学者利用物理共混、无规共聚、接枝共聚等方法对其进行改性，得到了应用性能较好的材料．近年来，有些学者利用缩合聚合的方法得到了PHB的嵌段共聚物，但是利用原子转移自由基聚合（ATRP）方法对PHB作嵌段共聚改性的研究尚未见报道．

英文摘要：

A new biodegradable PtBA-PHB-PtBA triblock copolymer was successfully synthesized by ATRP method with Br-PHB-Br as macroinitiator, ten-butyl acrylate as monomer and CuBr/PMDETA as the catalyst system. Cleavage of the tert-butyl ether groups of the PtBA-PHB-PtBA triblock copolymer was then performed via hydrolysis with trifluoroacetic acid as the catalyst in dichloromethane to afford the amphiphilic PAA-PHB-PAA triblock copolymer. The hydrolysis is successful but trace ten-butyl ether groups still remain in the backbone. The molecular weight characteristics and chain structures were conformed by GPC and NMR, respectively. Because of hydrophilic and biocompatibility, the amphiphilic triblock copolymers have potential applications in the field of drug release.