中文摘要：

目的将在犬的自体移植肝在 CD14 表示上学习 ischemia-reperfusion 损害(IRI ) 和肝的动脉局部缺血(HAI ) 的效果。方法肝 orthotopic 自体移植模型与是的 canines 随机划分了成一个控制组，同时的灌注(SR ) 组和 HAI 组的 30 健康男 Xi' 被使用。CD14 蛋白质表示， Malonaldehyde (MD A ) 在浆液在肝的纸巾和中高音价值满足被检测，并且肝的纸巾的病理学的变化在轻显微镜学下面被调查。结果在 SR 和 HAI 组的 CD14 蛋白质表示的水平趋于比有统计意义的控制高是时间依赖者和两个(P < 0.01 ) ；这二个组的山峰价值两个都在 HAI 组发生在 4 h，而是水平(11.94 卤 0.43 ) 在 SR 组比那显然高(3.04 卤 0.34 ) 。在肝织物，在浆液的中高音价值和病理学的变化的 MDA 内容作为 CD14 表示显示出一样的变化趋势。CD14 表示的结论 Up-regula-tion 可以是 Kupffer 房间(KC ) 的受体机制在肝移植的激活。在门静脉灌注以后的 HAI 罐头起来调整 CD14 表示，改进 KC 的活动推进更多，增加 OFR 生产并且与门灌注合作，并且最后加重接枝损害。

英文摘要：

Objective： To study the effect of ischemia-reperfusion injury（IRI） and hepatic artery ischemia（HAI） on CD14 expression in canine auto-transplantation livers. Methods：Liver orthotopic auto-transplantation models were applied with 30 healthy male Xi＇ an canines which were randomly divided into a control group, simultaneous reperfusion（SR） group and HAI group, CD14 protein expression, Malonaldehyde （MDA） Contents in hepatic tissues and ALT values in serum were detected, and the pathological changes of hepatic tissues was investigated under the light microscopy. Results：The level of CD14 protein expression in SR and HAI group tended to be time-dependent and both higher than controls with statistical significance（P 〈 0.01）; The peak values of these two groups both occurred at 4 h, but the level in HAI group （11.94 ± 0.43） was evidently higher than that in SR group（3.04 ± 0.34）. MDA contents in liver tissue, ALT values in serum and pathological changes showed the same changing tendency as CD 14 expression. Conclusion：（1） Up-regulation of CD14 expression may be the receptor-mechanism of Kupffer cells（KCs） activation in liver transplantation. （2） HAI can upregulate CD14 expression after portal vein reperfusion, improve the activity of KCs further more, increase OFRs production and cooperate with portal reperfusion, and finally aggravate the grafts injury.