欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的：研究藏红花素对小鼠创伤性脑损伤的保护作用和可能的机制。方法：采用控制性皮层撞击法建立小鼠创伤性脑损伤模型,通过脑含水量测定和运动功能评分评价藏红花素对小鼠创伤性脑损伤的保护作用。结果：①藏红花素显著减轻创伤性脑损伤后脑水肿程度。②藏红花素显著减轻创伤性脑损伤造成的运动功能损伤。③藏红花素显著提高了脑组织SOD和GPX的活性,降低了MDA水平。结论：藏红花素通过抗氧化活性对小鼠创伤性脑损伤发挥保护作用。
英文摘要：
Objective： To investigate the potential neuroprotective effects of crocin on traumatic brain injury in mice,as well as the potential mechanism.Methods： Brain water content and motor functional test were used to investigate the protective effects of crocin against traumatic brain injury,which was induced by a mice model of controlled cortical impact.Results： ① Crocin significantly reduced brain edema after traumatic brain injury.② Crocin obviously attenuated motor functional deficits induced by traumatic brain injury.③ Crocin markedly upregulated the activities of SOD and GPX,while downregulated MDA level.Conclusion： Crocin exerted a neuroprotective effect against traumatic brain injury through its antioxidative activities in mice.
同期刊论文项目
同项目期刊论文
The microsurgical treatment of cranio-orbital tumors assisted by intraoperative electrophysiologic m
Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusio
Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative s
Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitoc
Protective effect of Homer 1a on tumor necrosis factor-alpha with cycloheximide-induced apoptosis is
Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injur
Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate
VEGF upregulates Homer 1a gene expression via the mitogen-activated protein kinase cascade in cultur
Vascular Endothelial Growth Factor in Cerebral Ischemia (Retracted article. See vol. 90, pg. 1296, 2
期刊信息
位置：