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Current status and progress in gastric cancer with liver metastasis
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  • 分类:S858.31[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医] Q782[生物学—分子生物学]
  • 作者机构:[1]Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China, [2]School of Medicine, Nankai University, Tianjin 300071, China
  • 相关基金:This study was supported by the National Basic Science and Development Program (863 program No. 2006AA02A402) and National Natural Science Foundation of China (No. 30872468).
  • 相关项目:Dll4/Notch信号途径在肿瘤新生血管生成中的作用及其机制
中文摘要:

客观这评论与肝转移(GCLM ) 在胃的癌症上在研究讨论当前的地位和进步,包含 GCLM 的线路,子类型,和预后;与转移联系的基因和分子;每种成像形式的可行性和价值;并且当前的治疗 options.Data 采购在这评论使用的数据主要从从 2005 用英语出版到 2010 年 8 月的 Medline 和 PubMed。搜索词是“胃的癌症”和“肝转移”关于 GCLM 的治疗学的选择是的特征,诊断形式,和 vadous 的 .Study 选择文章 selected.Results GCLM 的预后被肝转移的主要肿瘤,以及存在的 clinicopathological 特征影响。相关基因和分子的改进理解将导致早察觉的方法的发展并且指向治疗。为 GCLM 的诊断,每种成像形式有它的相对好处。在那里不早关于治疗学的 options.Conclusions 仍然是一致肝转移的察觉和描述为胃的癌症病人的预后是关键的。多学科的队讨论被要求设计最佳的治疗策略,它应该基于每个病人的 clinicopathological 特征。

英文摘要:

Objective This review discusses the current status and progress in studies on gastric cancer with liver metastasis (GCLM), involving the routes, subtypes, and prognosis of GCLM; the genes and molecules associated with metastasis;the feasibility and value of each imaging modality; and current treatment options.Data sources The data used in this review were mainly from Medline and PubMed published in English from 2005 to August 2010. The search terms were "gastric cancer" and "liver metastasis".Study selection Articles regarding the characteristics, diagnostic modalities, and vadous therapeutic options of GCLM were selected.Results The prognosis of GCLM is influenced by the clinicopathological characteristics of primary tumors, as well as the presence of liver metastases. Improved understanding of related genes and molecules will lead to the development of methods of early detection and targeted therapies. For the diagnosis of GCLM, each imaging modality has its relative benefits. There remains no consensus regarding therapeutic options.Conclusions Early detection and characterization of liver metastases is crucial for the prognosis of gastric cancer patients. Multidisciplinary team discussions are required to design optimal treatment strategies, which should be based on the clinicopathological characteristics of each patient.

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