中文摘要：

目的：探讨运动频次和隔周递增强度运动对大鼠海马神经发生的影响。方法：将60只雄性5周龄SD大鼠随机分为安静对照（C）组、每天运动（E0）组、隔1日运动（E1）组、隔3日运动（E3）组、隔周运动（E7）组和隔周递增强度运动（E7I）组。运动方式为跑台运动。腹腔注射BrdU于各组大鼠,持续注射6天。采用免疫组织荧光染色技术,检测各组大鼠海马齿状回内新生细胞和新生神经元数量。结果：各组动物海马齿状回内BrdU免疫阳性（Br-dU＋）细胞数目为：C组37.62±9.02,E0组46.01±10.82,E1组49.06±12.07,E3组41.20±11.02,E7组37.23±16.45,E7I组53.97±10.67。各组大鼠海马齿状回内BrdU和NeuN免疫双阳性（BrdU＋＋NeuN＋）细胞数分别为：C组15.26±4.42;E0组17.61±3.86,E1组21.93±5.60,E3组16.28±5.37,E7组15.80±7.50,E7I组24.99±5.44。结论：在间隔不同时间的小强度运动中,隔日小强度运动最有利于大鼠海马齿状回神经发生;隔周递增运动强度也有利于大鼠海马齿状回神经发生。

英文摘要：

Objective： To investigate effects of movement frequency and incremental exercise intensity on hippocampal neurogenesis in rats. Methods.. Sixty male SD rats of 5-week-old were randomly divided into 6 groups ： The sedentary control （C） group, the everyday exercise （E0） group, the every other day exercise （ E1 ） group, the every three days exercise （ E3 ） group, the every other week exercise （E7）group and the every other week increasing intensity exercise （E7I） group. All rats except C group were forced to run on treadmill. Immunofluoreseence staining was used to evaluate the level of neurogenesis. Results：The number of BrdU positive cells in dentate gyrus of hippocampus was 37. 62±9.02 in C group,46.01± 10. 82 in E0 group,49.06 ± 12. 07 in E1 group, 41. 20 ± 11. 02 in E3 group, 37. 23 ± 16. 45 in E7 group, 53.97 ± 10.67 in E7I group, respectively. Conclusions ： Among all small intensity exercises which have different exercise frequency, the every other day exercise is most benefit of hippocampal neurogenesis in SD rats, the every other week increasing intensity exercise also is benefit of hip~pal neurogenesis in SD rats.