中文摘要：

背景：动脉瘤血液动力学变化为动脉瘤的治疗与其破裂的预防研究提供了前提与条件，有限元分析是一种很好的技术手段。 目的：构建颈内动脉瘤的双向流固耦合模型，并进行相关血流模拟。 方法：利用GE Lightspeed 64排螺旋CT扫描获得颈内动脉瘤CT血管造影数据，分别在mimics10.01软件上进行三维模型的实体构建，ansys＋fluent软件进行流固耦合及血流模拟与仿真。 结果与结论：构建了颈内动脉瘤瘤壁和流场的有限元模型，模型具有良好的解剖形态，并与实体模型一致。模拟展示整个心动周期的血流变化：瘤体血流呈漩涡样，瘤体部流速较瘤颈部慢；血流引起动脉瘤壁的形变、壁面剪切力、压力及应力以瘤颈部最大，瘤顶部最小。模拟值以0.16 s（快速射血期）时刻为最高值，0.74 s（舒张期）为最低值。结果显示基于CT血管造影扫描数据进行颈内动脉瘤的双向流固耦合建模，其方法简单、实用。模拟动脉瘤血流接近人体的生理状态，结果为研究动脉瘤发生、发展提供新的理论依据。

英文摘要：

BACKGROUND： The hemodynamics changes of aneurysm provide the basis for aneurysm treatment and ruptured aneurysm prevention, while finite element analysis is a good technical means. OBJECTIVE： To construct the two-way flow-solid coupling model of internal carotid artery aneurysm, and thus simulate its flows. METHODS： CT angiography data of internal carotid artery aneurysm were recorded with GE Lightspeed 64 spiral CT scanning, and the corresponding three-dimension model was constructed with mimics10.01 software. Then the fluid-solid coupled flow simulations were done depending on Ansys＋Fluent software. RESULTS AND CONCLUSION： The two-way flow-solid coupling model of internal carotid artery aneurysm was built, with the same morphology and anatomy as the three-dimensional CT imaging. In the whole cardiac cycle, the blood flow of aneurysm body was swirl typed and its velocity was slower than that of the aneurysm neck; the deformation, wall shear stress, pressure and von Mises stress of aneurysm wall were the maximum at the neck, and the minimum at the top. Their highest value was at the 0.16 s （rapid ejection period）, and their lowest value at the 0.74 s （relaxation period）. On the basis of CT angiography data, to construct the two-way flow-solid coupling model of internal carotid artery aneurysm is a simple and practical method. The blood flow simulation of aneurysm is close to the human physiological conditions, and the results will provide new theoretical basis for the study on the occurrence and development of aneurysm.