中文摘要：

目的通过观察加巴喷丁（GBP）对糖尿病周围神经痛（DPN）患者的疗效以及血清肿瘤坏死因子（TNF-α）、白介素-6（IL-6）的影响。方法 47例DPN患者按是否服用GBP随机分为GBP组24例与DPN对照组23例,糖尿病无神经痛患者25例为糖尿病（DM）组,成年健康体检者25例为正常对照（NC）组。观察DPN患者治疗前、治疗1、2、4 w后的视觉模拟评分（VAS）分值变化以及药物副作用。ELISA法测定血清中TNF-α、IL-6的水平。结果治疗前GBP组与DPN对照组VAS比较,差异无统计学意义（P〉0.05）;GBP组治疗后1、2、4 w VAS分值均显著下降,与治疗前及同期DPN对照组比较,差异有统计学意义（P〈0.01）;DPN对照组各时期VAS分值差异无统计学意义（P〉0.05）。DM、DPN各组血清TNF-α、IL-6均高于NC组,差异有统计学意义（P〈0.01）,DPN组血清TNF-α、IL-6又高于DM组,差异有统计学意义（P〈0.01,P〈0.05）;与治疗前比较,GBP组治疗后血清TNF-α、IL-6水平下降,差异有统计学意义（P〈0.01,P〈0.05）,DPN对照组治疗前后血清TNF-α、IL-6水平无明显变化,差异无统计学意义（P〉0.05）。治疗过程中有1例出现嗜睡,3例出现眩晕,但均可耐受,观察期间血常规、肝肾功能无明显变化。结论加巴喷丁治疗糖尿病神经痛效果确切,副作用轻微,可降低机体血清TNF-α和IL-6水平。

英文摘要：

Objective To investigate the effects of gabapentin（ GBP） on pain,tumor necrosis factor-α（ TNF-α）,and interleukin 6（ IL-6） level in the patients with diabetic peripheral neuralgia（ DPN）. Methods Periphera I blood samples were collected from DPN patients in the treatment with GBP（ GBP group,n = 24）,DPN patients without GBP treatment（ DPN control group,n = 23）,diabetic mellitus patients without DPN（ DM group,n = 25） and normal controls（ NC group,n= 25）. ELISA was used to detect the serum TNF-α and IL-6 levels. Visual analogue scale（ VAS） and adverse reactions were recorded before treatment and in 1,2,4 weeks after treatment. Results VAS in GBP group were significantly decreased in 1,2,4 weeks after treatment（ P 〈0. 01）. The serum TNF-α and IL-6 levels of the DM,DPN patients were all significantly higher than those of the NC group（ P 〈0. 01）. The serum TNF-α and IL-6 levels of the DPN patients were significantly higher than those of the DM group（ P 〈0. 01,P〈 0. 05）. The patients who received GBP had a significant change of serum TNF-α and IL-6 level after treatment（ P〈 0. 01,P 〈0. 05）. Adverse events in the therapy group were drowsiness（ 2 patients）,dizziness（ 3 patients）,but could be tolerated by patients. There were no significant alteration of blood routine,liver and kidney function. Conclusions Gabapentin is effective for the treatment of DPN and its adverse effects are mild. It can lower the serum TNF-α and IL-6 level in the patients with DPN.