中文摘要：

ObjectiveTo 调查在在使用的胶化包含的 sinapine thiocyanate 的 transdermal 举起上刺激 acupoints Feishu (BL 13 ) 和 Dazhui (GV 14 ) 的效果因为 asthma.MethodsThirty Sprague-Dawley 老鼠的管理随机用一张随机的数字桌子被划分成三个相等的组：Feishu (BL 13 ) acupoint 组或控制组。用 microdialysis 技术， preprocessed 皮探针被植入进老鼠在 Feishu (BL 13 ) ， Dazhui (GV 14 ) ，和一个 nonacupoint 地点。气喘胶化然后被放在皮肤上在为所有的 Feishu (BL 13 ) ， Dazhui (GV 14 ) acupoints，和 nonacupoint 组织。透析液被收集为 12 h 的每 30 min。在皮肤的 sinapine thiocyanate 的规范的集中被高效的液体 chromatography.ResultsThe 老鼠在 transdermal 实验表明了的 vivo 决定数量时间方程与零顺序的动力学显示出好线性关联(r > 0.99 ) 。transdermal 行为根据一阶的率是 transdermal 穿入率和在在 acupoint 地点的皮肤的 sinapine thiocyanate 的积聚的数量比通过 nonacupoint 地点的皮肤的那些大的开放在模型。在在 acupoint 组的 sinapine thiocyanate 的曲线下面的全身的最大的集中和区域比在 nonacupoint 组显著地大。A 落后时间在两个 acupoint 组被观察，然而并非在 nonacupoint group.ConclusionStimulating， acupoints 支持 sinapine thiocyanate 的经皮的吸收并且也控制它的版本，在血减少集中变化。

英文摘要：

OBJECTIVE： To investigate the effect of stimulating the acupoints Feishu（BL 13） and Dazhui（GV 14） on the transdermal uptake of sinapine thiocyanate contained in a gel used for the management of asthma.METHODS： Thirty Sprague-Dawley rats were randomly divided into three equal groups using a random number table： the Feishu（BL 13） acupoint group, the Dazhui（GV 14） acupoint group, and the nonacupoint group or control group. Using micro-dialysis technology, preprocessed skin probes were implanted into the rats at Feishu（BL 13）, Dazhui（GV 14）, and a nonacupoint site. Asthma gel was then placed on the skin at Feishu（BL 13）, Dazhui（GV14） acupoints, and the nonacupoint for all groups.Dialysate was collected every 30 min for 12 h. The normalized concentration of sinapine thiocyanate in the skin was determined by high-performance liquid chromatography.RESULTS： The rat in vivo transdermal experiment demonstrated that the quantity-time equation showed a good linear correlation with zero-order kinetics（r 〉 0.99）. The transdermal behavior was in accordance with the first-order rate open model in which the transdermal penetration rates and the accumulative amounts of sinapine thiocyanate in the skin at the acupoint sites were greater than those through the skin of the nonacupoint site. The systemic maximum concentration and the area under the curve of sinapine thiocyanate in the acupoint groups were significantly greater than in the nonacupoint group. A lag time was observed in both acupoint groups, but not in the nonacupoint group.CONCLUSION： Stimulating the acupoints promotes the percutaneous absorption of sinapine thiocyanate and also controls its release, reducing concentration fluctuations in the blood.