下丘脑食欲素(orexin)是调节睡眠与觉醒、饮食行为、情感、自主神经活动以及全身糖代谢的主要神经肽之一。本文综述了下丘脑orexin在机体糖代谢平衡中的主要作用,阐述了orexin在糖代谢中的作用模式及其分子机制。
Hypothalamic orexin are known to regulate sleep/wake,feeding behavior,emotions,autonomic nerve activity,and whole-body glucose metabolism.This review mainly discussed the mian roles of orexin in glucose metabolism balance,and the action model and molecular mechanism in glucose metabolism.