欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
乙酰肝素酶（heparanase,Hpa）是哺乳动物细胞中唯一能切割细胞外基质（extra cellular matrix,ECM）中硫酸乙酰肝素（heparin sulfate,HS）侧链的内切性糖苷酶,在肿瘤发生发展的各个阶段尤其是肿瘤转移中起到重要的作用。有关Hpa的研究近年来一直受到广泛关注,该文综述了Hpa在肿瘤组织中的表达及调控,旨在为以Hpa为靶点的肿瘤治疗提供依据。
英文摘要：
Heparanase is the only found mammalian β-glueuronidase to promote heparin sulfate （HS） cleavage within extra cellular matrix. Heparanase is implicated to possess great significance in a variety of pathologies, such as tumor growth, angiogenesis, glomerular diseases, and especially tumor metastasis. Heparanase overexpression in a variety of malignant tumors suggests that it could be a target for anti-cancer therapy. This paper explains expression and regulation of heparanase in tumor cells to provide information for using Hpa as targets for drug development.
同期刊论文项目
同项目期刊论文
3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Ak
Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases th
Connections Between Various Trigger Factors and the RIP1/ RIP3 Signaling Pathway Involved in Necropt
Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL-induced apoptos
Connexin-dependent gap junction enhancement is involved in the synergistic effect of sorafenib and a
Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells th
期刊信息
位置：