中文摘要：

目的：研究阿托伐他汀对急性百草枯中毒大鼠肺损伤的保护作用及机制。方法：将40只SD大鼠随机分为正常对照组,单纯染毒组,阿托伐他汀治疗低、高剂量组。染毒组和治疗组百草枯80 mg/kg灌胃1次;治疗低、高剂量组分别给与阿托伐他汀20、40 mg/kg灌胃7 d。解剖动物,取肺组织行苏木精-伊红（HE）染色,检测超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）水平。结果：HE染色结果：染毒组肺损伤较其它各组明显严重,治疗组肺损伤减轻。SOD、GSH-PX测定结果：染毒组与对照组相比明显降低（P〈0.05）,各治疗组与染毒组相比均有明显升高（P〈0.05）,治疗组间有统计学差异（P〈0.05）。结论：阿托伐他汀对鼠急性百草枯中毒肺有保护作用,可增加SOD、GSH-PX的活性。

英文摘要：

Objective： To study the effects of atorvastatin in protect the lung injury induced by acute paraquat poisoning in rats.Methods： Forty SD rats were divided into four groups： control,paraquat poisoning model,treat with low dosage and high dosage atorvastatin group.Paraquat poisoning model group and the treatment groups were given paraquat 80 mg·kg-1 gavage for one time;The treatment groups were respectively given atorvastatin 20 mg·kg-1·d-1,40 mg·kg-1·d-1 gavage for 7 days.The animals were anesthetized and got the lung tissue,then observed the pathological changes by HE staining,and study the changes of SOD and GSH-PX.Results： The result of HE Staining： The lung injury of paraquat poisoning lung is obviously serious than other groups.Treatment groups reduce the lung injury.SOD,GSH-PX determination results： The level of SOD,GSH-PX were significantly lower in poisoning group than those in control group（P0.05）.After seven days treatment,a significant increasing occurred in SOD,GSH-PX level with a dose-dependent manner（P0.05）.Conclusion： Atorvastatin significantly attenuated lung injury induced by acute paraquat poisoning.Its mechanism might be related to the activity increase of SOD、GSH-PX.