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丁丙诺啡舌下片合并东莨菪碱、异丙嗪静脉注射对认知功能的影响

ISSN号：1007-9718
期刊名称：《中国药物依赖性杂志》
时间：0
分类：R996[医药卫生—毒理学;医药卫生—药学] R971.92[医药卫生—药品;医药卫生—药学]
相关基金：受国家重点基础研究发展计划（973）课题（2003CB515400）和国家自然科学基金（30370522）资助

关键词：丁丙诺啡, 东莨菪碱, 异丙嗪, 静脉注射, 药物滥用, 认知功能, buprenorphine, scopolamine, promethazine, intravenous, drug abuse, cognitive function

中文摘要：

目的：了解丁丙诺啡舌下片合并东莨菪碱、异丙嗪静脉注射（简称“1＋1”）对认知功能的影响.方法：对60例“1＋1”滥用者、60例海洛因依赖对照者采用韦氏记忆量表、Stroop测验以及威斯康星卡片分类测验工具,分别对其记忆、注意和执行功能进行测试.结果：“1＋1”滥用组的记忆商数（76.78±s 18.62）明显低于海洛因对照组（95.67±s14.62）,尤其以视觉再认、图片回忆、视觉再生、触摸记忆、理解记忆和背诵数目为甚（P＜0.001）;“1＋1”滥用组的Stroop（C、CW）总时间、ST-C中不正确数和纠正数高于海洛因对照组,差异有显著性（P＜0.01）;“1＋1”滥用组的WCST-M测验的分类错误数、持续错误总数高于海洛因对照组,正确分类个数低于对照组,差异有统计学意义（P＜0.05）.结论：“1＋1”滥用者在使用上述药物后,即使未再使用海洛因,但认知损害仍在继续加重,主要表现为大脑记忆、注意和执行功能方面存在不同程度的损害.

英文摘要：

Objective： To investigate the effect of intravenous abuse of buprenorphine tables, scopolamine and promethazine, which was abbreviated to be ＂1 ＋ 1＂ abuse in China, on the cognitive function of its abusers. Methods： Cognitive function of 60 ＂1 ＋ 1＂ abusers and 60 heroin addicts as control was assessed with a battery of neuropsychological evaluation instruments in Changsha, China. The tools included Wechsler Memory Scale - revised test （WMS）, Stroop Test （C, CW） and Modified Wisconsin Card Sorting Test （WCST - M）. Results： The memory quotient and the scores on such factors as vision recognition, picture recall, design reproduction, touch memory, story recall as well as digit span of the ＂1 ＋ 1＂ abusers （76.78±s 18.62） were significantly lower than those of the heroin addicts control group （95.67±s 14.62）, P 〈 0.001. There was significant difference between the two groups in the time spent in Stroop test （C, CW）, the number of errors and rectification in Stroop - C test, with the ＂1 ＋ 1＂ abusers spending more time in Stroop test （C, CW）, and having more errors and rectification in Stroop - C test. （P 〈 0.01） Furthermore, the ＂1 ＋ 1＂ abusers had more scores in total, persistent errors, and lower number of categories in WCST, showing statistical significant difference （P 〈 0.05）. Conclusion： Certain cognitive dysfunction, such as memory, attention and executive function is observed in the ＂1 ＋ 1＂ abusers in our objects. The impairment of cognitive function, which has been caused by heroin abuse, continue to aggravate, even if the ＂1 ＋ 1＂ abusers only use the intravenous form of buprenorphine tables, scopolamine and promethazine, while keeping abstinence to heroin.

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