中文摘要：

核仁磷蛋白（nucleophosmin，NPM）突变是近几年才提出的一个在急性髓系自血病中发挥重要作用的基因改变，对其分子调控机制的深入研究将有利于进一步阐述白血病的发病机制，并为白血病的临床治疗提供更多的理论依据。该文介绍核仁磷蛋白突变的特点、参与调控白血病的可能机制以及核仁磷蛋白突变指标检测的临床价值等。

英文摘要：

Nucleophosmin mutations, which have been described recently, play an important role in acute myeloid leukemia （AML）. Studying the molecular mechanisms of nucleophosmin mutations would be beneficial to elaborate the pathogenesis of AML and provide more theoretical basis for the clinical treatment of AML. In this paper, the characters and the possible regulation mechanisms of nucleophosmin mutations in AML and the clinical value of the detection of nucleophosmin mutations were reviewed.