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重组人血管内皮抑制素联合放射治疗对lewis肺癌小鼠的作用
  • 期刊名称:中国肺癌杂志
  • 时间:0
  • 页码:386-390
  • 分类:R735.3[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构:[1]武汉大学人民医院肿瘤科,湖北武汉430060
  • 相关基金:国家自然科学基金资助项目(编号:30970860)
  • 相关项目:Endostar联合放疗影响肺癌供血供氧和细胞内氧感受器表达的机制研究
中文摘要:

目的:通过1例残胃癌术后多处淋巴结转移探讨内皮抑素(恩度)联合放疗的近期疗效、毒副反应及耐受性。方法:根据PET-CT指引给予高代谢灶放疗,放疗期间每周一、周三、周五给予内皮抑素15 mg/d。按照RE-CIST标准评价近期疗效,参照PS评分变化评价生活质量(QOL),按照NCI CTC 3.0版标准评价毒性反应。结果:该例患者治疗后疗效评价为完全缓解,PS评分提高到0分,主要毒副反应为Ⅲ度骨髓抑制。结论:内皮抑素联合放疗治疗残胃癌术后多处淋巴结转移具有良好的近期疗效,可改善患者生活质量,毒性较低,安全性和耐受性好。

英文摘要:

Objective: To evaluate the effects,toxicities and tolerance of concurrent recombinant human endostatin combined with radiotherapy for the treatment of one case of remnant gastric cancer with multiple lymph node metastasis after operation.Methods: The patient received radiotherapy in high metabolic lesions by PET-CT.The recombinant human endostatin was given as a dossage of 15 mg per day every other day during radiotherapy.The efficacy was evaluated according to RECIST criteria,quality of life(QOL) was evaluated by performance status(PS),and safety was evaluated according to NCI CTC 3.0 version criteria.Results: The efficacy of this patient was complete remission(CR).The performance status(PS) was advanced to 0 point,while the main toxicity was marrow suppression of grade Ⅲ.Conclusion: Recombinant human endostatin combined with concurrent radiotherapy is effective for remnant gastric cancer patients with multiple lymph node metastasis after operation,and can improve the quality of life with low toxicity and fine tolerance.

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