中文摘要：

采用阳极氧化法在钛表面制备不同管径的TiO2纳米管,450℃热处理后经牛血清白蛋白（BSA）与钙磷的共沉积得到载有BSA的羟基磷灰石（HA）涂层.经检测发现,170nm管径的TiO2表面比100和50nm管径的表面具备更好的矿化能力,HA的形成能力随管径的增大而提高.大管径表面得到的涂层结合强度高于小管径的,可达16.95MPa.经过真空预矿化的试样,涂层结合强度明显高于未经过预矿化的试样,且HA涂层生长速率加快.BSA与磷酸钙在真空预矿化后共沉积到氧化钛纳米管表面,短时期内形成BSA-HA涂层,是在钛基生物材料表面制备生物活性涂层的有效方法.

英文摘要：

TiO2 nanotubes on titanium with different diameters were prepared by anodic oxidation after heat-treated at 450℃.Hydroxyapatite（HA） coatings containing bovine serum albumin（BSA） were produced on the nanostructured surface through biomimetic co-deposition.The TiO2 nanotube layers with 170nm diameter has a better mineralization ability compared that with diameter of 100nm and 50nm,And the HA formation ability is enhanced with increase of the diameters.The bonding strength of the coating to the nanotube layers with large diameter is higher than that with small diameter,and the maximal strength can reach 16.95MPa.Moreover,the pre-mineralization in vacuum signifi-cantly enhances the bonding strength,and increases growth rate of the coating.The BSA-HA coating with high bond-ing strength can fastly form on TiO2 nanotube layers by pre-mineralization in vacuum and then biomimetic co-deposition,which would be a promised method for preparing titanium-based bioacitive coatings.