中文摘要：

Stat5是信号转导和转录活化蛋白（signal transduction and activator of transcription,Stat）家族的重要成员,它有两个序列高度同源的亚型Stat5a和Stat5b。与其他成员相比,Stat5参与了更为广泛的细胞生理调控过程。Stat5能够影响细胞的增殖、分化、存活与凋亡,并且在乳腺发育、免疫应答、干细胞自我更新调控、造血作用以及肿瘤的发生发展等中具有重要作用。本文综述了Stat5的信号转导机制及其生物学功能的研究,并探讨了今后在这一领域可能的发展方向。

英文摘要：

tat5 is an important member of signal transduction and activator of transcription（Stat） protein family.It has two highly homologous isoforms： Stat5a and Stat5b.Compared with other members,Stat5 is involved in a broader spectrum of cellular physiological regulation processes.Stat5 can not only contribute to cellular functions of proliferation,differentiation,survival and apoptosis,but also play important roles in mammary gland development,immune response,stem cell self-renewal regulation,hematopoiesis as well as tumors development and progression.This review summarizes the signal transduction mechanisms and the biological functions of Stat5.And we further discuss and predict the future progress in this field.