中文摘要：

近年来,丝状真菌次级代谢产物的研究在国内外受到了极高的重视,同时也取得了较大的进展。本文对丝状真菌次级代谢产物的生物合成和调控机制以及隐性次级代谢产物生物合成基因簇的激活等方面进行了简述,同时对组合生物学给真菌次级代谢产物研究带来的机遇和挑战进行了讨论。

英文摘要：

In made great the fungal filamentous discussed recent years, the study of secondary metabolites in filamentous fungi has been paid more and more attention and progress. In this paper, we reviewed the recent research progresses on the biosynthesis, regulatory mechanisms of secondary metabolites and the activation of the cryptic secondary metabolites biosynthetic gene clusters in fungi. Opportunities and challenges on fungal secondary metabolites research from combinatorial biology are