以β-磷酸三钙(βTCP)和壳聚糖(CS)为主要原料,采用反相乳液悬浮法制备出β-TCP/CS复合微球,并经1150℃条件下烧结,得到主要成分为卢.TCP的无机微球。X射线衍射分析得到经烧结后微球相成分主要为伊TCP,扫描电镜观察微球形貌表明微球成球性好、表面粗糙,激光粒度分析仪测定微球粒径主要分布在150-450μm。生物实验表明微球具有良好的生物活性。
The β-TCP/CS composite microspheres were prepared by a solid-in-water-in-oil (s/w/o) emulsion cross-linking method, which were sintered at 1150℃to obtain β-TCP microspheres. XRD results showed that the crystal phase of the sintered microspheres was β-TCP. The surface morphology and microstructure were evaluated by SEM, and the size distributions were mainly distributed in 150μm-450μm. And the porosity, bulk density and apparent density of β-TCP microspheres were measured by mercury porosimeter. Cells cultured experiments presented the good biocompatibility of β-TCP microspheres. The results indicate that the β-TCP-based microspheres are potential materials as tissue engineering scaffolds for bone repair.