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标准化测量海马体积

ISSN号：1003-3289
期刊名称：《中国医学影像技术》
时间：0
分类：R322.81[医药卫生—人体解剖和组织胚胎学;医药卫生—基础医学] R445.2[医药卫生—影像医学与核医学;医药卫生—诊断学;医药卫生—临床医学]
作者机构：[1]首都医科大学宣武医院放射科,北京100053, [2]民航总医院放射科,北京100123, [3]中国科学院生物物理研究所脑与认知科学国家重点实验室,北京100101
相关基金：国家863计划项目（2006AA02z391）; 国家973计划项目（2005CB522800、2004CB318101）; 国家自然科学基金（30621004）

作者：张勇[1,2], 陈楠[1], 王星[1], 卓彦[3], 陈霖[3], 李坤成[1]

关键词：海马, 磁共振成像, 人体测量, Hippocampus, Magnetic resonance imaging, Anthropometry

中文摘要：

目的分析中国健康成人海马体积与颅内容积（IVC）之间的关系,寻找一种可靠的海马体积校正方法。方法对1000名健康成年人行大脑T1加权三维磁化强度预备梯度回波序列扫描。应用三维体积分析软件手工勾画感兴趣区域的方法测量海马的体积,并按头颅高径、前后径、左右径相乘的方法测量IVC。从中选取18～60岁800名健康成人的脑MRI数据,应用相除法和协方差法分析海马体积与IVC的相关性。分别对1000名健康成年人左、右侧的海马原始体积、经相除法和协方差法校正后的海马体积进行不同性别间两独立样本t检验。结果左、右侧海马体积与IVC呈正相关（r=0.55、0.49,P均〈0.001）。经相除法校正后,左、右侧海马体积与IVC的相关性较校正前减低（左侧：r=-0.33,F=10.11,P〈0.01;右侧r=-0.29,F=7.46,P〈0.01）。经协方差法校正后,左、右侧海马体积与IVC无相关性（左侧：r=0.13,F=1.40,P=0.24;右侧：r=0.10,F=0.76,P=0.39）。1000名健康成年人左、右侧的海马原始体积在不同性别间差异有统计学意义（t=7.326、6.586,P均〈0.001）;采用相除法校正后的左、右侧海马体积在不同性别间的差异亦有统计学意义（t=-3.753、-3.287,P均〈0.001）;采用协方差法校正后的左、右侧海马体积在不同性别间的差异无统计学意义（左侧：t=-0.526,P=-0.179;右侧：t=-1.353,P=-0.600）。结论海马结构体积与IVC间存在明显相关关系,相除法和协方差法可以有效地对海马体积进行校正,有助于更客观地判断海马体积变化。

英文摘要：

Objective To analyze the relationship between the hippocampal volume and intracranial volume in healthy Chinese adults, in order to provide a reliable correction method of hippocampal volume measurement. Methods A total of 1000 healthy Chinese adults, ranging from 18 to 76 years-old, underwent cranial MR scan with T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequences. Hippocampal volume was measured using manual drawing region of interest with three-dimensional volume analysis software. Intracranial volume was obtained when head height diameter was multiplied by anteroposterior diameter by width. Since the cranial cavity volume and hippocampal volume were relatively stable during 18—60 years, 800 adults aged from 18 to 60 were selected for volume correction analysis using the division and covariance method. Then the hippocampal volume in different gender and side in 1000 healthy Chinese adults was corrected and analyzed by t-test. Results Hippocampal volume in left and right side was both related to intracranial volume （r=0.55, 0.49, all P0.001）. Left and right side of hippocampal volume after correction by the division was related to intracranial volume （left side： r=-0.33, F=10.11, P0.01; right side： r=-0.29, F=7.46, P0.01）. But no correlation of hippocampal volume was found between left and right side after covariance correction （left side： r=0.13, F=1.40, P=0.24; right side： r=0.10, F=0.76, P=0.39）. In 1000 healthy Chinese adults, the difference of original hippocampus volume between different gender was apparent （t=7.326, 6.586, both P0.001）. The right and left hippocampal volume were different between different gender using division method corrected （t=-3.753, -3.287, both P0.001）, but no difference was found when covariance method was used （left side： t=-0.526, P=-0.179; right side： t=-1.353, P=-0.600）. Conclusion Hippocampal volume is obviously related to intracranial volume. The division method and the covariance method can ef

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