中文摘要：

近10多年来随着色谱（气相色谱和液相色谱）和高分辨率质谱联用技术以及相关数据处理软件和数据库的发展,使得高通量的非目标化合物分析方法得以实现,并在环境研究、食品监管、药物研发以及生物代谢物研究等领域得到日益广泛的应用.本文综述了基于气相/液相色谱-高分辨率质谱联用技术的非目标化合物分析方法的研究进展,包括其分析方法策略、流程及其在环境研究领域的实际应用情况,并探讨了该方法所存在的问题和发展前景,为环境中的新兴污染物及其代谢转化产物、关键致毒物的甄别、环境健康风险评估等提供一种新兴的高通量分析鉴别技术.

英文摘要：

Over the past decade, with the development of high-resolution mass spectrometry（ HRMS） coupled to gas liquid chromatography（ GC /LC）,and specialized data-processing software and database,the high-throughput method of non-target analysis is realized. The state-of-the-art analytical methods is increasingly applied in the fields of environmental studies,food regulation,drug development,biological metabolites,and so on. This review summarizes the advance of the non-target analytical methods based on GC / LC-HRMS,including analytical strategies and analytical procedures,and the practical applications of the methods in the field of environmental studies. The problems and prospects of the applications are also discussed. This method can be used as a highthroughput analysis identification technique for the environmental studies,such as the fields of emerging pollutants and their metabolic products, effect-directed analysis（ EDA）, andenvironmental health risk assessment.