因为他们是安逸的胀大并且不能支持房间生长,木钉相关的粘合剂在临床的使用被限制。在这研究,我们与高粘合剂力量生产了一系列修改 POSS 的木钉粘合剂。无机的恐水病的 POSS 单位的介绍减少了粘合剂和提高的细胞粘附和生长胀大。在里面 vitro cytotoxicity 并且在 vivo,煽动性的反应实验清楚地证明粘合剂是无毒、拥有的优秀 biocompatibility。与 sutured 创伤相比,对待粘合剂的创伤在 Bama 缩小的猪的受伤的皮模型显示出一个加速的愈合的过程,证明修改 POSS 的木钉粘合剂是创伤闭合的一个有希望的候选人。
PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure.