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POSS-modified PEG Adhesives for Wound Closure
  • ISSN号:0256-7679
  • 期刊名称:《高分子科学:英文版》
  • 时间:0
  • 分类:TQ24[化学工程—有机化工] TQ432.2
  • 作者机构:[1]Beifing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry Institute of Chemistry, Chinese Academy of Sciences, Beifing 100190, China, [2]University of Chinese Academy of Sciences, Beijing 100049, China, [3]Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, China
  • 相关基金:This work was financially supported by the National Natural Science Foundation of China (Nos. 21674120, 81630056 and 21474115), PLA (No. AWS 14C003) and "Young Thousand Talents Program".
中文摘要:

因为他们是安逸的胀大并且不能支持房间生长,木钉相关的粘合剂在临床的使用被限制。在这研究,我们与高粘合剂力量生产了一系列修改 POSS 的木钉粘合剂。无机的恐水病的 POSS 单位的介绍减少了粘合剂和提高的细胞粘附和生长胀大。在里面 vitro cytotoxicity 并且在 vivo,煽动性的反应实验清楚地证明粘合剂是无毒、拥有的优秀 biocompatibility。与 sutured 创伤相比,对待粘合剂的创伤在 Bama 缩小的猪的受伤的皮模型显示出一个加速的愈合的过程,证明修改 POSS 的木钉粘合剂是创伤闭合的一个有希望的候选人。

英文摘要:

PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure.

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期刊信息
  • 《高分子科学:英文版》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:中国化学会 中国科学院化学研究所
  • 主编:
  • 地址:北京2709信箱
  • 邮编:100080
  • 邮箱:wangj@iccas.ac.cn
  • 电话:010-62562417 62588927
  • 国际标准刊号:ISSN:0256-7679
  • 国内统一刊号:ISSN:11-2015/O6
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),荷兰文摘与引文数据库,美国剑桥科学文摘,美国科学引文索引(扩展库),英国高分子图书馆,日本日本科学技术振兴机构数据库,中国中国科技核心期刊
  • 被引量:103