以大豆蛋白为天然高分子基材,通过原位聚合法制备了大豆蛋白基聚N-异丙基丙烯酰胺(SPI-PNIPAm)微球.采用透射电镜、粒径仪、红外光谱等手段对微球的形貌、结构进行了表征,并对微球的药物可控释放性能进行了研究.结果表明,SPI-PNIPAm对模型药物罗丹明B具有可控释放性能,释放时间长达15h以上.
Soybean protein isolate-poly (N-isopropyl acrylamide) SPI-PNIPAm) nanospheres have been prepared via in-situ polymerization,and characterized by transmission electron microscopy,dynamic light scattering and FT-IR.Release experiments of Rhodamine B show that these biopolymer nanoparticles provide a controlled release of the entrapped drugs for 15 h.