中文摘要：

目的：探讨伏立康唑治疗儿童急性白血病并发侵袭性真菌感染的有效性及安全性.方法：选择48例经临床资料和/或生物学证实儿童白血病并发侵袭性真菌感染的患者,均使用伏立康唑治疗,第1天予以负荷剂量为6 mg/kg,静脉滴注,每12 h 1次,随后予维持剂量为4 mg/kg,静脉滴注,每12 h 1次,用药时间5～28 d,中位数为11 d,并对用药前后患者肝、肾功能及电解质进行监测.结果：伏立康唑临床总有效率为72.92%,真菌清除率为78.26%,只有少数患者发生轻度肝功能损害、胃肠道反应、视觉异常等不良反应.结论：伏立康唑因其抗菌谱较广,耐药性少,在治疗儿童急性白血病侵袭性真菌感染中有非常好的疗效,毒副作用少,该药是一种安全高效的抗真菌药物.

英文摘要：

Objective：To analyze the cilinal efficacy and security of voriconazole on invasive fungal infections in children with acute leukemia. Methods ：48 children patients with acute leukemia suffered from invasive fungal infections were di- agnosed by clinical or/and biological data. All of them were treated with intravenous voriconazole 6 mg/（ kg · d）. q 12 h at the first day, and then treated with intravenous voriconazole 4 mg/（kg · d）. q 12 h for 5 ~28 days, the median is 11 days, observing the liver and renal function, electrolytes during the treated time. Results：The overall efficacy rate of voriconazole was 72.9% in 48 patients, the fungus clearance rate was 78.2%, only a few patients with the adverse effect of liver dysfunction or gastrointestinal react or paropsis. Conclusion： Voriconazole injection is effective and safe in the treatment of invasive fungal infections in children with acute leukemia.