氡是排第2位的肺癌致病因子。职业流行病学调查证实,高浓度的氡暴露可增加肺癌发生的危险度;动物实验和体外研究表明,氡对肺支气管和骨髓的效应是多方面的,多数毒性作用有剂量-效应关系;氡染毒后,某些基因和蛋白有差异性表达。降氡、戒烟和药物都可减少肺癌的相对危险度。
Radon has been considered as the second agent leading to lung cancer. High concentration of radon exposure may increase the risk of lung cancer, which has been confirmed by epidemiologic investigation. Animal test and in vitro experiment show that the biological effects of radon on lung, bronchi and bone marrow are dose-related, with differential expressions of genes and proteins upon radon exposure. Radon reducing, smoke quitting and propolis may decrease the relative risk of lung cancer.