中文摘要：

缺血再灌注损伤是器官移植、缺血性休克、器官切除手术中常见的病理生理过程,也是导致器官功能障碍和术后严重并发症的重要影响因素,如何避免和减轻器官缺血再灌注损伤一直是研究的热点。NLRP3炎性小体被认为是触发机体炎症反应的重要环节,在IL-1β和IL-18炎性因子成熟活化过程中具有不可或缺的作用。本文就近年来对NLRP3炎性小体在器官缺血再灌注损伤中的研究做一综述。

英文摘要：

Ischemia-reperfusion injury is a common pathophysiological process in organ transplantation, ischemic stroke and organ resection surgery, and also an important factor causing organ dysfunction and severe postoperative complications. How to avoid or mitigate organ ischemia-reperfusion injury has always been a research hotspot. NLRP3 Inflammasome has been considered to be an important link in inflammatory response. It has an indispensable role in maturation process of IL-1β and IL-18. We reviewed the research in recent yeas about the role of NLRP3 Inflammasome in organ ischemia-reperfusion injury in this paper.