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中文摘要：
肿瘤抑制因子CYLD（Cylindromatosis，头帕肿瘤综合征蛋白）是一种去泛素化酶，哕埘基因突变或者缺失导致圆柱瘤，并与多种肿瘤的发生、发展密切关联。CYLD通过自身去泛素化酶活性移除特定底物的K63连接的泛素链，并负调控包括NF-κB在内的多条信号通路。在生理条件下，通过磷酸化修饰和泛素化修饰，CYLD的蛋白表达量和活性受到严格的调控。CYLD与多种细胞学功能相关，如细胞运动和迁移、免疫和炎症反应、破骨细胞的形成等。
英文摘要：
The tumor suppressor CYLD （Cylindromatosis） is a deubiquitinase. Mutation or deletion in cyld gene induces cylindromatosis. This gene also has been associated with several types of carcinoma. It has been shown that CYLD negatively regulates different signaling pathways including NF-κB and INK pathway by removing lysine 63-linked polyubiquitin chains from several specific substrates. CYLD is regulated by different mechanisms, such as phosphorylation and ubiquitination. CYLD participates in various cellular processes, ranging from immune responses and inflammation to cell cycle control and osteoclastogenesis.
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