中文摘要：

二苯丙氨酸二肽（L-Phe-L-Phe,FF）是引起阿尔兹海默症的A？-多肽成纤维的关键识别序列,具有优异的自组装性能,是制备生物功能性纳米材料的重要组装基元.迄今为止,研究者已制备出多种FF基微纳米结构,但是如何有效地控制自组装材料的形状和尺寸一直都是研究的关键和热点.近年来,本课题组通过改变组装条件以及引入外源小分子等方法来调控FF基肽分子的组装,成功实现了对肽基组装材料的形状、结构和功能的调控.这些研究不仅丰富了FF基肽分子的组装结构,同时也为其他肽基纳米材料的制备和生物功能材料的开发提供了新的策略和重要的实验依据.

英文摘要：

The self-assembly of biomaterials to form well-ordered hierarchical structures provides great opportunities in biomedical applications. In the past decades, a great many of researches have been focused on self-assembly of peptide molecules owing to their structural simplicity, chemical versatility, biocompatibility, facile synthesis, and widespread applications. Well defined peptide assemblies could be effectively achieved by hydrogen bonding, electrostatic, hydrophobic and ？-？ stacking interactions. One well-known and the simplest peptide building block is diphenylalanine（FF）, the core recognition motif of the Alzheimer＇s ？-amyloid polypeptide. It is a major building block for the preparation of biological functional nanomaterials. So far, researchers have developed a variety of FF-based micro/nanostructures, such as nanotubes, microtubes, microrods, nanowires, and nanovesicles, etc. However, how to effectively control the shape and size of the self-assembled materials has always been the key concern of the research. In recent years, our group has conducted substantial researches on controlled assembly of FF and its derivatives by simply changing the assembly condition（solvents, peptide concentrations, ultrasonic） or introduction of exogenous small molecules（polyoxometalates, sulfonic azobenzenes, aldehydes）. For example, our group obtained hexagonal FF microtubes in water and peonylower-like mesocrystal in the organic solvent tetrahydrofuran. When the organic solvent was changed to chloroform or toluene, FF organogels were obtained. Moreover, the structural transition from organogels to flower-like microcrystals were observed by changing the components of solvent. Similarly, upon a change in the peptide concentration, reversible shape transition between self-assembled dipeptide nanotubes and vesicle-like structures is achieved. In view of positive charge of cationic dipeptide, negatively charged small molecules（polyoxometalates and sulfonic azobenzenes） were added into the assembly syste