中文摘要：

Candida albicans 是能响应许多环境刺激从酵母经历词法转变到 hyphae 的人的病原的真菌。我们分析了 C。是的蛋白质完全七填写了的 albicans Asc1 (Cyp1 的生长 Suppressor 的缺席) WD 领域重复，并且从真菌被保存到后生动物。在 C 删除 ASC1。albicans 在检验的导致 hypha 条件下面在菌丝的开发导致了一个深刻缺点。而且， ASC1 的删除稀释了 C 的毒力。在全身的感染的一个老鼠模型的 albicans。这些数据强烈建议保存 WD 重复蛋白质 Asc1 为 C 的形态发生和致病被要求。albicans。

英文摘要：

Candida albicans is a human pathogenic fungus which can undergo a morphological transition from yeast to hyphae in response to a variety of environmental stimuli. We analyzed a C. albicans Ascl （Absence of growth Suppressor of Cypl） protein which is entirely composed of seven repeats of the WD domain, and is conserved from fungi to metazoan. Deleting the ASC1 in C. albicans led to a profound defect in hyphal development under hypha-inducing conditions examined. Furthermore, deletion of the ASC1 attenuated virulence of C. aibicans in a mouse model of systemic infection. These data strongly suggested that the conserved WD-repeat protein Ascl is required for morphogenesis and pathogenesis of C. albicans.