中文摘要：

背景：脾机能亢进和免疫者的致病与门静脉高血压(PH ) 在病人怒气工作仍然保持阴暗。这研究试图由于 PH 与脾机能亢进在怒气评估血怒气障碍的词法变化并且为怒气的有免疫力的功能的深入的调查向证据提供脾机能亢进和脾机能亢进的机制。方法：从有怒气的创伤的破裂的 12 个门 hypertensive 病人和 4 个病人的怒气样品被检验。怒气的样品被转变为病理学的节，与马森一起染色了三色的污点， Gomori 污点，和 CD68， CD34 免疫组织化学，并且是为在骨胶原纤维，网状纤维，巨噬细胞，和脉管的 endothelial 的分发的变化的检验用显微镜。在在缘带的巨噬细胞和 endothelial 的超微结构的变化被传播电子显微镜学也评估。结果：作为与正常怒气相比，在 PH 怒气的巨噬细胞的密度被减少，但是巨噬细胞主要位于缘带并且在脾小结附近散布了，与房间表面上的许多绒毛和像伪足的伸出。骨胶原纤维的增生在脾小结和中央动脉附近是明显的。增加的 reticulate 纤维环绕了有在纤维之间的更多的连接的脾小结。脉管的 endothelial 在传播分发，没有在 PH 怒气的任何 regionality，但是有扩大的腔的容器在红髓增加了。结论：血怒气障碍的词法变化能是为有免疫力的功能的反常和与 PH 位于病人的怒气的血细胞的增加的破坏的病理学的臀部之一。然而，这仍然必要澄清。

英文摘要：

The pathogenesis of hypersplenism and the immune function of the spleen in patients with portal hypertension （PH） remain obscure. This study aimed to evaluate the morphological changes of blood spleen barrier in spleen with hypersplenism due to PH and provide evidence for an in-depth investigation of the immune function of the spleen with hypersplenism and the mechanism of hypersplenism. Methods Spleen samples from 12 portal hypertensive patients and 4 patients with traumatic ruptures of spleen were examined. The samples of spleen were made into pathological sections, stained with Masson trichrome stain, Gomori stain, and CD68, CD34 immunohistochemistry, and were examined microscopically for the changes in the distribution of collagen fibers, reticular fibers, macrophages, and vascular endothelial cells. The changes in ultrastructure of macrophages and endothelial cells in marginal zone were also evaluated by transmission electron microscopy. Results As compared to the normal spleen, the density of macrophage in the PH spleen was decreased, but the macrophages were mainly located in the marginal zone and distributed around the splenic corpuscle, with many villi and pseudopodium-like protrusion on the cell surface. The accrementition of collagen fibers was obvious around the splenic corpuscle and central artery. The increased reticulate fibers encircled the splenic corpuscle with more connection between the fibers. The vascular endothelial cells were in diffused distribution, without any regionality in PH spleen, but the vessel with enlarged lumina increased in red pulp. Conclusions The morphological changes of the blood spleen barrier can be one of the pathological fundaments for the abnormality of the immune function and the increased destruction of blood cells located in the spleens of patients with PH However. this still entails clarification.