中文摘要：

选择碳化二亚胺法，使大豆皂苷单体Ab分别与十二烷胺、苯乙胺发生缩合反应，在Ab的C-3-O葡萄糖醛酸羧基上形成酰胺键，得到两种非极性强的衍生物，并利用傅里叶红外光谱、质谱、核磁共振等方法加以鉴定。合成的目标衍生物可用于深入探讨大豆皂苷及其衍生物与其免疫佐剂活性的定量构效关系研究。

英文摘要：

The natural structure of saponins may not stay in the best active state. To enlarge its application and gain inten- sive insight into the relationship between structure and function, modification of sugar chains in soyasaponins is required. Derivatives of soyasaponin Ab were prepared by adding either dodecylamine or phenylethylamine in the presence of car- bodiimide. The semi-synthesized derivatives of soyasaponin Ab with weak polarity were identified by IR, EMI-MS, and NMR. The derivatives can be used for further exploration of the relationship between immunostimulating adjuvant/haemo- lytic activities and molecular structure of soyasaponins and their derivatives.