中文摘要：

AIM： to evaluate the protective effect of bicyclolagainst bile duct ligation （BDL）-induced hepatic fibrosisin rats.METHODS： Sprague-Dawley male rats underwentBDL and sham-operated animals were used as healthycontrols. The BDL rats were divided into two groupswhich received sterilized PBS or bicyclol （100 mg/kgper day） orally for two consecutive weeks. Serum, urineand bile were collected for biochemical determinations.Liver tissues were collected for histological analysisand a whole genome oligonucleotide microarray assay.Reverse transcription-polymerase chain reaction andWestern blotting were used to verify the expression ofliver fibrosis-related genes. RESULTS： Treatment with bicyclol significantly reducedliver fibrosis and bile duct proliferation after BDL.The levels of alanine aminotransferase （127.7 ± 72.3vs 230.4 ± 69.6, P 〈 0.05） and aspartate amino-RESULTS： Treatment with bicyclol significantly reducedliver fibrosis and bile duct proliferation after BDL.The levels of alanine aminotransferase （127.7 ± 72.3vs 230.4 ± 69.6, P 〈 0.05） and aspartate am