随着纳米技术的迅速发展,纳米科学与肿瘤医学相结合形成的纳米肿瘤医学是纳米科学中新兴的重要领域。金纳米棒(GNR),一种棒状的纳米材料,由于其独特光学性质在生物医学领域展现出巨大应用潜力,尤其是GNR的热疗,放射增敏作用以及对肿瘤的靶向性治疗方面。GNR联合内放疗靶向性治疗肿瘤作为一种新兴疗法,对肿瘤的靶向性治疗取得了优异的疗效。本文对GNR联合内放疗靶向性肿瘤治疗的机制及其近年来的研究应用作一综述。
With the rapid development of nanotechnology, nano oncology medicine that is formed through the combination of nano science and oncology medicine has become an important field emerging in nano science. Because of its unique optical properties, the gold nanorod(GNR), that is a rod-shaped nano materials, has shown great potential applications in the biomedical field, especially, in GRNs thermotherapy,radio-sensitizing effect therapy and targeting therapy of the tumor. Being a newly-developed therapy, gold nanorods combined with internal radiotherapy has already obtained excellent durative effect in targeting therapy of tumor. This paper aims to make a comprehensive review about its mechanism and its clinical application and research situation in recent years.