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人类基因组的研究策略和应用
  • 项目名称：人类基因组的研究策略和应用
  • 项目类别：创新研究群体科学基金
  • 批准号：30221004
  • 申请代码：C0605
  • 项目来源：国家自然科学基金
  • 研究期限：2003-01-01-2008-12-31
  • 项目负责人：杨焕明
  • 负责人职称：研究员
  • 依托单位：中国科学院北京基因组研究所
  • 批准年度：2002
中文摘要：

创新团体在项目执行过程中开展了一系列关于水稻基因组分析和功能基因组研究，以及合成生物学方面的工作，取得了重大科研成果 1．通过杂交水稻及其父本和母本的基因组，转录组和蛋白组水平的分析， 以及不同生长发育时期、不同组织器官的转录组和蛋白组水平的比较，揭示杂交稻中基因的表达与调控、互作网络的特点，分析了杂种优势的分子机制； 2．通过比较栽培稻不同株系与野生稻之间SNP 的分布情况，鉴定出可能与"家养化"相关的SNP deserts区域，这些区域内的基因具有较高的Ka/Ks值，在水稻家养化过程中受正选择，分析发现，50%的已克隆的家养化相关的基因位于SNP deserts区域,揭示我们分析发现的SNP deserts区域是家养化相关基因的热点区域,进一步基因功能分析正在进行中； 3.以生物信息学设计为基础，以 "最小基因组"为起点，构建了具特异基因回路并能合成特异有用产物的人造细菌株。

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  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
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期刊论文
Detailed comparison between the wheat chromosome group 7 short arms and the rice chromosome arms 6S
Differential gene expression in an elite hybrid rice cultivar (Oryza sativa, L) and its parental lin
From Rice Genomic Sequences To Rice Gene Chips
Proteomic profiling of rice embryos from a hybrid rice cultivar and its parental lines.
Life is Beautiful - from DNA to the Human Genome Project in China
Biotechnology and Health: A Global Response to the Global Challenges
Genomics in China: Strengths, Challenges, and Drivers.
Genome Biology: The Second Modern Synthesis
Genomics and Development of the Developing Countries
Genome Sciences – Rice and Beyond.
正反向测序信息在全基因组序列拼接及分析中的应用.
Proteomic changes in rice leaves during development of field-grown rice plants.
Humanitarian Challenges, Global Responsibilities and Global Strategies for Biotechnology.
ReAS: Recovery of Ancestral Sequences for High-Copy Transposable Elements in Plant Genomes.
BGI-RIS: an integrated information resource and comparative analysis workbench for rice genomics.
Gene Identification and Expression Analysis of 86,136 Expressed Sequence Tags (EST) from the Rice Ge
Identification and characterization of insect-specific proteins by genome data analysis.
High rate of chimeric gene origination by retroposition in plant genomes.
A cross-species alignment tool (CAT).
HRGD: a database for mining potential heterosis-related genes in plants.
A comparison of rice chloroplast genomes.
Modeling Transcriptome Based on Transcript-Sampling Data.
An improved method of sample preparation on Anchorchip targets for MALDI MS and MS/MS and its applic
Proteomic and transcriptomic analysis of rice mature seed-derived callus differentiation.
Pedigree analysis of an elite rice hybrid using proteomic approach.
The Rice (Oryza sativa L.) Mitochondrial Genomes and Their Variations.
Serial Analysis of Gene Expression Study of a Hybrid Rice Strain (LYP9) and Its Parental cultivars.
A Brief Introduction to Genome Research at BGI
FGF: a web tool for Fishing Gene Family in a whole genome database.
Seeking for transformation markers: An analysis of differential proteomes on the rice germplasm gene
A protein chip approach for high-throughput antigen identification and characterization.
The genomes of Oryza sativa: A history of duplications.
Gene conversion in the rice genome.
TreeFam: 2008 Update.
Snap: An Integrated SNP Annotation Platform.
PigGIS: Pig Genomic Informatics System.
Genes controlling seed dormancy and pre-harvest sprouting in a rice-wheat-barley comparison,
水稻U-Box蛋白质在不同发育时期的表达分析
亚洲人二倍体基因组测序完成
超级杂交水稻LYP9及其亲本的转录组学研究
Evolutionary Transients in the Rice Transcriptome
会议论文
The proteomic comparison of the rice with and without the transformation of genomic DNAs from Echino
运用多种蛋白质组分析方法鉴定水稻叶片中RuBisCo在生长过程中变化.
The Chinese Superhybrid Rice Genome Project
The Proteomic Dynamics of Rice Leaf in Six Different Growth Periods.
Recent Development of the Superhybrid Rice Genome Project in China
Monitoring the changes of leaf proteomes during development in field-grown rice plant.
Comparative Analysis of the Rice Genome
Pedigree analysis of an elite rice hybrid using proteomic approach.
A survey of dynamic proteomes from rice tissues at different phases of growth.
Studying hybrid vigor with genomics tools
The Rice genomics and its implications for crop genomics
转稗草基因水稻的蛋白质组学研究.
籼稻9311在不同生长时期的水稻穗蛋白质组比较.
The Genome Sequences of indica and japonica rice.
A survey of dynamic proteomes from rice tissues at different phases of growth
水稻根在不同生长时期的蛋白质组动力学研究.
转螺旋藻基因水稻的叶片蛋白质组分析.
Europe’s Global Responsibilities.
ommon Threats, Common Thrivings and the Common Thread
Genomics and Developing Countries
Sdg近等基因系间水稻茎的差异蛋白质组分析.
The Proteomic Changes During Maturation of Rice Ear.
Ethical Issues in Biotechnology
获奖
中国科学院
日本“Nikkei”基金会
中国科学院
日本“Nikkei”基金会
杨焕明的项目
1%人类基因组计划“完成图”的绘制
期刊论文 4 会议论文 7 著作 1
第二届中印基因组信息学研讨会
国际基因组学大会(北京)
分子医学人类基因组学知识与技术的应用研讨会（北京）
中印生物信息学研讨会