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数学方法在计算分子生物学中的应用
  • 项目名称：数学方法在计算分子生物学中的应用
  • 项目类别：面上项目
  • 批准号：10571019
  • 申请代码：A011403
  • 项目来源：国家自然科学基金
  • 研究期限：2006-01-01-2008-12-31
  • 项目负责人：王天明
  • 负责人职称：教授
  • 依托单位：大连理工大学
  • 批准年度：2005
中文摘要：

计算分子生物学作为数学、计算机科学、化学等多学科交叉形成的一门崭新的学科，主要是研究分子生物学中基因和蛋白质序列有关的复杂计算问题。所使用的数学工具有组合数学、组合优化、数理统计等。我们将在RNA二级结构组合计数、生物序列的相似性分析和比较、基因识别、种族树的构建等方面进行研究运用Bell 多项式和反演技术考虑不带假结的RNA二级结构计数，并建立它与格路之间的关系，将结构量化，寻求新的数学理论；进而利用分拆理论考虑带假结二级结构的最小自由能和结构预测；给出DNA序列和RNA二级结构合理的几何图形表示，并探索生物序列数据特征的生物学意义；利用数值特征比较DNA序列和RNA二级结构的相似性，将相似性转化为距离记分构建进化树；构建更加有效的基因识别的优化模型，提高处理庞大数据量时的可靠性；给定一组基因在不同条件下表达水平的数据，对基因间是否存在相互协同作用及相互作用的强度做出统计推断。

中文主题词： 组合计数;RNA二级结构;生物序列图形表示;进化树;蛋白质
成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 41
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期刊论文
Comparison of TOPS strings based on LZ complexity
On property of the invariant of graphical representations of DNA sequences
A weighted measure for the similarity analysis of DNA sequences
Related matrices of DNA primary sequences based on triplets of nucleic acid bases
Characterization of protein primary sequences based on partial ordering
A new mapping rule for RNA secondary structures with its applications
A novel 2D graphical representation of DNA sequences and its application
A New Enumeration Problem of RNA Secondary Structure
On graphical and numerical representation of protein sequences
Use of linear regression model to compare RNA secondary structures
2D representation of protein secondary structure sequences and its applications
Feature analysis of protein structure by using discrete Fourier transform and continuous wavelet tra
Asymptotic enumeration of RNA secondary structure
Novel characterization of the folding of proteins
Condensed representations of protein secondary structure sequences and their application
PNN-curve: A new 2D graphical representation of DNA sequences and its application
A method for rapid similarity analysis of RNA secondary structures
The enumeration of various types of constrained secondary structure
Analysis of protein sequences and their secondary structures based on transition matrices
C(i,j) matrix: A better numerical characterization for graphical representations of biological seque
Numerical characterization of DNA sequences based on the kQi-step Markov chain transition probabilit
Comment on 'Analysis of similarity/dissimilarity of DNA sequences based on a 3-D graphical represent
Comparison study on k-word statistical measures for protein: From sequence to 'sequence space'
On 3D graphical representation of RNA secondary structures and their applications
Linear regression model of DNA sequences and its application
A simple method for protein structural classification
Graphical representations for protein secondary structure sequences and their application
A new method to analyze the similarity of the DNA sequences
A 3D graphical representation of RNA secondary structures based on chaos game representation
Markov model plus k-word distributions: a synergy that produces novel statistical measures for seque
Use of statistical measures for analyzing RNA secondary structures
Comparing RNA molecules based on their secondary structures.
The enumeration and asymptotics of RNA secondary structures.
A Discrimination Measure for Phylogenetic Tree Construction
Protein-based phylogenetic analysis by using hydropathy profile of amino acids
A computational method for the similarity analysis of RNA secondary structures and its application
A representation of DNA primary sequences by random walk
一种用于蛋白质相似性分析的新的相对距离
RNA二级结构的6-D表示及相似性分析
RNA二级结构预测及其数学描述
1种基于信息理论的新分子序列度量法
会议论文
Comparing RNA secondary structures based on their linear representations.
著作
计算生物学导论
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王天明的项目
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