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中文摘要：
本项目以肉类制品中常见残留兽类药物为研究对象, 特别是多种药物小分子与生物大分子血清白蛋白(或DNA)共存时, 对它们相互作用的机理及涉及生物信号转导和测试数据解析进行深入的研究。联用多种测试手段和实验技术对此类生物体系的热力学和动力学信号进行测量和采集, 获取多维数据并建立扩展的生物体系测量数据矩阵群(expanded data matrix);进而利用化学计量学-多维数据辨析法处理和解析数据，实现生物体系信号的合理和有效解析, 并充分提取生物体系信息，对药物的毒性或药效作出解释，得到合理的结果; 并努力改进适用于生物信号转导及信息提取的更为有效的化学计量学计算方法。本项目是将化学生物学和化学计量学相结合的一项基础性的研究，其意义在于探索一条能深入研究小分子和生物大分子作用过程、实现生物信号有效解析的新方法和新途径。
英文摘要：
Multi-way calibration；biomacromolecule；Veterinary drugs；Interactions；
结论摘要：
本项目以肉类制品中常见残留兽类药物为研究对象, 特别是多种药物小分子与生物大分子血清白蛋白(或DNA)共存时, 对它们相互作用的机理及涉及生物信号转导和测试数据解析进行深入的研究。联用多种测试手段和实验技术对此类生物体系的热力学和动力学信号进行测量和采集, 获取多维数据并建立扩展的生物体系测量数据矩阵群(Expanded data matrix);进而利用化学计量学-多维数据辨析法处理和解析数据，实现生物体系信号的合理和有效解析, 并充分提取生物体系信息，对药物的毒性或药效作出解释，得到合理的结果; 并努力改进适用于生物信号转导及信息提取的更为有效的化学计量学计算方法。本项目是将化学生物学和化学计量学相结合的一项基础性的研究，其意义在于探索一条能深入研究小分子和生物大分子作用过程、实现生物信号有效解析的新方法和新途径。
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期刊论文
A novel electrochemical method for the analysis of hydrogen peroxide with the use of a glassy carbon
Analysis of complex, processed substances with the use of NIR spectroscopy and chemometrics: Classif
Unmodified silver nanoparticles for rapid analysis of the organophosphorus pesticide, dipterex, ofte
A high performanceliquid chromatography and electrospray ionization mass spectrometry method for the
A novel near-infrared spectroscopy and chemometrics method for rapid analysis of several chemical co
Glassy carbon electrodes modified with gold nanoparticles for the simultaneous determination of thre
Voltammetric behavior of complexation of salbutamol with calf thymus DNA and its analytical applicat
Simultaneous Spectrophotometric Kinetic Determination of Four Flavor Enhancers in Foods with the Aid
Study of the interaction between 10-hydroxycamptothecine and DNA with the use of ethidiurn bromide d
RESOLUTION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC FINGERPRINTS OF RHIZOMA CURCUMAE BY APPLICATIO
Application of multiway-variate calibration to simultaneous voltammetric determination of three cate
Using Fast Gas Chromatography-Mass Spectrometry with Auto-Headspace Solid-Phase Microextraction to D
Investigation of the pharmacokinetics and determination of certain cephalosporins in rabbit plasma b
Spectrophotometric analysis of phenols, which involves a hemin-graphene hybrid nanoparticles with pe
Competitive interactions of anti-carcinogens with serum albumin: a spectroscopic study of bendamusti
Investigations of an electrochemical platform based on the layered MoS2-graphene and horseradish per
A near-infrared reflectance spectroscopy method for direct Analysis of several chemical components a
A novel dsDNA/polydiphenylamine-4-sulfonic acid electrochemical biosensor for selective detection of
Graphene oxide as a nanocarrier for loading and delivery of medicinal drugs and as a biosensor for d
Simultaneous determination of caffeine, theophylline and theobromine in food samples by a kinetic sp
A novel electrochemical biosensor based on the hemin-graphene nano-sheets and gold nano-particles hy
A glassy carbon electrode modified with poly(anthranilic acid), poly(diphenylamine sulfonate) and Cu
A high-performance chromatography method for quality control of complex substances: analysis of mark
INTERPRETING ANALYTICAL CHEMISTRY DATA: RECENT ADVANCES IN CURVE RESOLUTION WITH THE AID OF CHEMOMET
Combined voltammetric and spectroscopic analysis of small molecule-biopolymer interactions: The levo
Fluorescence Spectral Analysis for the Discrimination of Complex, Similar Mixtures with the Aid of C
Multiway calibrations based on spectrofluorimetric data derived from kinetic analysis of the hydroly
A novel method for simultaneous analysis of three beta(2)-agonists in foods with the use of a gold-n
Analysis of HPLC fingerprints: discrimination of raw and processed Rhubarb samples with the aid of c
A kinetic spectrophotometric method for simultaneous determination of phenol and its three derivativ
Simultaneous determination of three 5-nitroimidazoles in foodstuffs by differential pulse voltammetr
Two-dimensional fingerprinting approach for comparison of complex substances analysed by HPLC-UV and
Near-infrared spectra combined with partial least squares for pH determination of toothpaste of diff
Spectrophotometric study of the interaction between chlorotetracycline and bovine serum albumin usin
Simultaneous kinetic spectrometric determination of three flavonoid antioxidants in fruit with the a
One- and two-dimensional gas chromatography-mass spectrometry and high performance liquid chromatogr
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