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中文摘要：
本课题旨在前期研究基础上，以中药整体观和多成分、多靶点协同作用特点为切入点，充分考虑中药体内过程中化学物质的变化，模拟中药在体内进行生物活性表达的一些关键步骤，建立中药有机整体中化学物质的生物分离新模式和被分离成分LC/MS 在线结构鉴定的研究方法，构建中药复杂体系药效物质基础的吸收、分布、代谢、与靶细胞结合的体外研究技术平台,并应用建立的技术平台，对当归补血汤、四逆汤等中药复方进行研究。
结论摘要：
英文主题词bioactivity based separation; complex TCMs; multi-components and multi-targets; active components; novel quality control approach
成果综合统计
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期刊论文
Application of liquid chromatography-electrospray ionization time-of-flight mass spectrometry for an
Rapid separation and identification of 54 major constituents in Buyang Huanwu decoction by ultra-fas
Simultaneous determination of twelve bioactive constituents in Buyang Huanwu decoction by HPLC-DAD-E
Screening and identification of permeable components in combined prescription of Danggui Buxue Decoc
A new method to identify active components of traditional Chinese medicine using dialysis and high p
Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liq
Plasma pharmacokinetics, tissue distribution and excretion study of 6-gingerol in rat by liquid chro
Direct on-line analysis of neutral analytes by dual sweeping via complexation and organic solvent fi
Rapid and sensitive analysis of tannins and monoterpene glycosides in Radix Paeoniae Alba products b
Simultaneous determination of flavonoids and saponins in Semen Ziziphi Spinosae (Suanzaoren) by high
Structural characterization and identification of C19-and C20-diterpenoid alkaloids in roots of Acon
High-speed separation and characterization of major constituents in Radix Paeoniae Rubra by fast hig
Structural characterization of pregnane glycosides from Cynanchum auriculatum by liquid chromatograp
Screening and identification of potential bioactive components in a combined prescription of Danggui
Multiple Target Cell Extraction and LC-MS Analysis for Predicting Bioactive Components in Radix Salv
Simultaneous determination of bioactive constituents in Danggui Buxue Tang for quality control by HP
Improved quality control method for Fufang Danshen preparations through simultaneous determination o
Analysis of chemical and metabolic components in traditional Chinese medicinal combined prescription
Simultaneous determination of seven active components of Fufang Danshen tablet by high performance l
Live cell extraction and HPLC-TOF-MS analysis for predicting bioactive components of Radix et Rhizom
Identification of chemical and metabolic components of Fufang Danshen prescription by high performan
Comparison of oil-in-water and water-in-oil microemulsion electrokinetic chromatography as methods f
On-line concentration of neutral analytes by complexation and acetonitrile sweeping in nonionic micr
Qualitative and quantitative analysis of Radix Astragali products by fast high-performance liquid ch
Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isofl
Simultaneous determination of 15 marker constituents in various Radix Astragali preparations by soli
Determination of fifteen bioactive components in Radix et Rhizoma Salviae Miltiorrhizae by high-perf
Advances of modern chromatographic and electrophoretic methods in separation and analysis of flavono
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