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中文摘要：
有四条细胞信号转导途径的异常与肿瘤的发生有密切关系，它们包括TGF－周期素途径、p19－p53途径、端粒酶途径和Ras－MARP途径。这些信号转导途径既独立又相互影响，以这些信号转导途径中的分子为靶点可寻找新型特异性抗肿瘤药物。其中端粒酶作为肿瘤治疗的新靶点，正日益受到生物医学界的广泛注意。利用新型的以生物热力学为基础，快速有效的竞争平衡透析法来筛选对人类端粒核酸序列及结构具有特殊识别能力配体，结合TRAP方法和比较不同端粒酶抑制剂对多种肿瘤细胞凋亡的作用效果并考察CDK抑制蛋白的表达水平，利用拉曼光谱分析技术以及局部蛋白质组和相互作用组学方面研究的开展对从整体水平上解析不同端粒酶抑制剂对端粒酶信号转导途径的影响，动物模型实验的开展更好的从活体水平上评估该活性药物的有效性，进一步为端粒酶抑制剂的临床应用提供丰富的理论依据和实验佐证。
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