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中文摘要：
本项目设计合成了胍基修饰的磁性纳米粒子、CdTe量子点掺杂的磁性核壳纳米粒子等新型多功能磁性核壳纳米材料，对其形貌和顺磁性等性质进行了表征。结果表明，所制备的纳米粒子具有所希望的特征官能团和超顺磁性，对蛋白质混合样品中的酸性蛋白质具有良好的富集能力和分离效果；还建立了一种用Fe(III)-磁性纳米颗粒螯合物作为涂层剂共价修饰毛细管内壁的新型柱涂层技术，建立了分离磷酸类蛋白和非磷酸类蛋白的毛细管电泳新方法。实验结果表明，用自行合成的新型磁性纳米涂层材料修饰后的毛细管可以使在未涂层毛细管中难以分离的血清白蛋白、β-酪蛋白、血红蛋白、卵清蛋白得到很好的分离，该方法已成功用于牛奶中提取的复杂磷酸类蛋白与非磷酸类蛋白混合物的分离。此外，本项目还建立了四种毛细管电泳在线富集新技术，合成了新型纳米探针并研究了其在分析化学中的应用。本项目的开展和研究显著提高了毛细管电泳对蛋白质的分离和检测能力，不仅使其能够更好地满足蛋白质组学研究的要求，而且对纳米分析化学和生命分析化学的发展具有重要意义。
结论摘要：
英文主题词New functional magnetic core-shell nanoparticles; Capillary electrophoresis; Preconcentration and separation of protein; Nano-analytical chemistry.
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期刊论文
Thousand fold concentration of an alkaloid in capillary zone electrophoresis by micelle to solvent s
Fe(3+)-immobilized nanoparticle-modified capillary for capillary electrophoretic separation of phosp
Preparation of Guanidine Group Functionalized Magnetic Nanoparticles and the Application in Preconce
Assessment for the light-induced cis-trans isomerization of rhapontigenin and its glucoside rhaponti
Preparation and characterization of hexadecyl functionalized magnetic silica nanoparticles and its a
Study on the interaction of phthalate esters to human serum albumin by steady-state and time-resolve
Di-n-amyl L-tartrate-boric acid complex chiral selector in situ synthesis and its application in chi
A novel cross-H-channel interface for flow injection-capillary electrophoresis to reduce sample requ
Complexes between CI Acid Orange 6 and human serum albumin, a multi-spectroscopic approach to invest
Application of molecular modelling and spectroscopic approaches for investigating binding of vanilli
Determination of Melamine in Dairy Products, Fish Feed, and Fish by Capillary Zone Electrophoresis w
On-line combination of single-drop liquid-liquid-liquid microextraction with capillary electrophores
Aqueous Synthesis of CdTe/CdSe Core/Shell Quantum Dots as pH-sensitive fluorescence probe for the de
Analysis of ammonia and aliphatic amines in environmental water by micellar electrokinetic chromatog
Effect of molecular structure of tartrates on chiral recognition of tartrate-boric acid complex chir
In situ synthesis of di-n-butyl L-tartrate-boric acid complex chiral selector and its application in
NMR, multi-spectroscopic and molecular modeling approach to investigate the complexes between C.I. A
Flow injection-capillary electrophoresis frontal analysis method for the study of the interactions o
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