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中文摘要：
本项目拟将菌类微生物(如水藻、孢子和酵母菌)及其复合材料作为基质，将表面印迹技术分别与牺牲基质法、原子转移自由基聚合和磁性载体分离技术耦合，分别制备出中空的、尺寸可控的和磁性的印迹聚合吸附剂，并引入发酵液中目标抗生素(以四环素类、磺胺类和青霉素类抗生素为研究对象)的靶向、快速和高效分离提取。探讨抗生素在发酵液界面和印迹聚合物界面之间的行为；研究表面分子印迹生物及其复合材料对抗生素的分离提取机理，建立相应的热力学及动力学模型；结合先进的表征手段，研究印迹聚合吸附剂的物理、化学特性，解释印迹聚合、选择性吸附和分离提取过程中的平衡、动力学和热力学特性；研究三类印迹聚合吸附剂选择性分离提取发酵液中抗生素的应用可行性、可靠性和比较优势。
英文摘要：
Surface imprinting technique；Molecular imprinted polymer；Antibiotics；Selective separation；Microbial
结论摘要：
本课题采用废弃壳聚糖、纤维素和微生物及其复合物作为印迹载体，结合表面分子印迹技术，利用沉淀聚合法、细乳液聚合、Pichering乳液聚合、原子转移自由基聚合技术和智能型分离技术结合，制备出具有磁、温度响应性的智能型印迹聚合物；研究了印迹聚合物对抗生素和菊酯类农药的靶向、快速和高效分离提取。利用静态吸附实验，探讨了吸附剂对抗生素和菊酯类农药的吸附分离与富集的平衡、动力学和选择性识别行为，并建立了相应的热力学及动力学模型；结合先进的表征手段，研究印迹聚合吸附剂的物理、化学特性，解释印迹聚合、选择性吸附和分离提取过程中的平衡、动力学和热力学特性。制备的印迹聚合物吸附剂具有成本低廉、机械性能强、热稳定性好、预定性、识别性和实用性等优点。主要研究成果有目前已发表SCI学术论文46篇，授权国家发明专利3项。
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期刊论文
Highly-controllable imprinted polymer nanoshell at the surface of silica nanoparticles based room-te
Surface imprinted core-shell nanorod with ultrathin water-compatible polymer brushes for specific re
Magnetic imprinted nanomicrosphere attached to the surface of bacillus using miniemulsion polymeriza
One-Pot Method for Obtaining Hydrophilic Tetracycline-ImprintedParticles via Precipitation Polymeriz
Versatile Method To Obtain Homogeneous Imprinted Polymer ThinFilm at Surface of Superparamagnetic Na
Acid–chromic chloride functionalized natural clay-particles for enhanced conversion of one-potcellul
Selective removal of erythromycin by magnetic imprinted polymers synthesized from chitosan-stabilize
Thermo-responsive and magnetic molecularly imprinted Fe3O4@carbon nanospheres for selective adsorpti
Thermoresponsive and magnetic molecularly imprinted polymers based on iron oxide encapsulated carbon
Narrowly dispersed imprinted microspheres withhydrophilic polymer brushes for the selectiveremoval o
HIPEs template: Towards the synthesis of polymeric catalysts with adjustable porous structure, acid–
Fabrication of free-standing bio-template mesoporous hybrid film for high and selective phosphate re
Fabrication and evaluation of molecularly imprinted regenerated cellulose composite membranes via at
Simple synthesis of thioglycolic acid-coated CdTe quantum dots as probes for Norfloxacin lactate det
Design of mesoporous silica hybrid materials as sorbents for the selective recovery of rare earth me
Facile polymerizable surfactant inspired synthesis of fluorescent molecularly imprinted composite se
Synthesis of macroporous polymer foams via pickering high internal phase emulsions for highly effici
Surface molecularly imprinted polymers based on yeast prepared by atom transfer radical emulsion pol
Composites of surface imprinting polymer capped Mn-doped ZnS quantum dots for room-temperature phosp
A simple and sensitive surface molecularly imprinted polymers based fluorescence sensor for detectio
Selective separation of salicylic acid from aqueous solutions using molecularly imprinted nano-polym
Selective removal of 2,4-dichlorophenol in aqueous solutions by nanoparticles modified yeast using m
Synthesis of molecularly imprinted silica nanospheres embedded mercaptosuccinic acid-coated CdTe qua
Molecularly imprinted polymer microspheres for optical measurement of ultra trace nonfluorescent cyh
Well-designed multihollow magnetic imprinted microspheres based on cellulose nanocrystals (CNCs) sta
Br？nsted Acidic Polymer Nanotubes with Tunable Wettability toward Efficient Conversion of One-Pot Ce
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