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中文摘要：
复杂天然产物有效成分的分离制备一直是分离科学研究中的难点之一，而逆流色谱技术的发展与应用无疑提供了新的手段。为了切实提高逆流色谱的分离制备性能并将该技术有效地应用在复杂结构天然产物的快速分离中，本项目拟构建一套新型多维逆流色谱系统。在该系统中首次将"洗脱/推出"技术应用于真实的复杂体系中，充分利用逆流色谱液相固定相的特点，拓宽被分离样品的极性范围，使其在第一维达到高效的分步分离。所得到的各流分通过自行设计的在线浓缩装置、样品环以及柱切换系统转入第二维色谱柱中进行二次分离，在保持色谱制备性能的同时，增强逆流色谱的分离效率，从根本上避免两维洗脱条件的干扰，提高分辨率和峰容量，缩短分离时间。本项目拟将该多维逆流色谱系统应用于复杂的天然产物体系中，通过对其中的一系列化学组分快速、制备性的分离研究，发展并建立可应用于天然产物有效成分的多维逆流色谱分离方法，奠定该方法的应用基础并丰富分离科学理论.
结论摘要：
英文主题词Complex system;novel multidimensional counter-current chromatographic technique;rapid separation and preparation
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期刊论文
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