欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
位置：立项数据库 > 立项详情页
中文摘要：
用逆行束路追踪结合免疫电镜双重标记染色法、免疫组织化学法和原位分子杂交组织化学技术，观察腹外侧眶皮层(VLO)内GABA能中间神经元与投射到导水管周围灰质（PAG）的神经元之间的突触联系；GABA(A/B)受体、μ-阿片受体、5-HT1/2受体的分布与其mRNAs表达；用脑片膜片钳技术记录VLO神经元的微小抑制性突触后电流(mIPSC)和GABA(A/B)受体激动剂、拮抗剂对mIPSC的影响。在此基础上，观察μ-阿片和5-HT1/2受体激动剂和拮抗剂对mIPSC的影响，以及参与细胞内信号转导的腺苷酸环化酶、磷脂酶C、蛋白激酶A和蛋白激酶C的抑制剂对上述激动剂效应的影响。为阐明VLO内阿片和5-HT诱发的抗伤害效应是通过抑制GABA能中间神经元对投射到PAG的神经元的紧张性抑制（去抑制），导致激活VLO-PAG脑干下行抑制系统的假设提供形态与机能学证据，具有重要的理论意义和潜在的应用价值。
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Involvement of μ- and δ-opioid receptors in mediatiing the nucleus submedius (Sm) opioid-evoked anti
The role of 5-HT receptor subtypes in the ventrolateral orbital cortex of 5-HT-induced antinocicepti
Mu- but not delta- and kappa-opioid receptors in the ventrolateral orbital cortex mediate opioid-ind
Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ve
The roles of different subtypes of opioid receptors in mediating the nucleus submedius opioid-evoked
The effects of microinjection of morphine into thalamic nucleus submedius on formalin-evoked nocicep
Roles of different subtypes of opioid receptors in mediating the ventrolteral orbital cortex opioid-
Effect of stimulation and lesion of the thalamic nucleus submedius on formalin-evoked nociceptive be
Microinjection of serotonin into the ventrolteral orbital cortex produces antinociception mediated b
Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-imag
GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT(1A) receptor activation-in
Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid
相关项目
唐敬师的项目