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中文摘要：
为了实现高通量、高特异性和高灵敏度的生物分子检测，我们提出发展一类集新型分子识别技术、超精细结构非传统加工、集成微流芯片实验室和现代光谱学与成像技术于一体的新方法。这一方法将电化学分子识别技术与现代激光光谱学和红外成像技术结合，两种手段互相补充用于进一步提高识别的特异性和检测的准确度。通过纳米尺度的超精细结构制备与微米尺度的大规模集成微流芯片技术相结合，采取非传统的微纳加工方法，提高微流芯片的检测通量和灵敏度，并实现操作和检测的全自动化。结合集成芯片和光学成像等高通量手段和电化学、光谱学的高灵敏度检测方法，在有限的空间和时间内对微量样品进行更加全面的分析，突破传统技术的在通量、精度上的局限和对样品量的依赖。
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期刊论文
Quantitative detection of adenosine in urine using silver enhancement of aptamer-gold nanoparticle a
Qualitative and quantitative thrombin analysis in serum using aptamers and gold nanoparticles throug
Processing of graphen for electrochemical application: noncovalently functionalize graphene sheets w
A Simple and Sensitive Biosensor Based on Silver Enhancement of Aptamer-Gold Nanoparticle Aggregatio
Maximum Entropy Method for Analyses of Fluorescence Correlation Spectra of Oligonucleotide Intra-Cha
Subdomain-specific collapse of denatured staphylococcal nuclease revealed by single molecule FRET me
Cation and anion substitution effects on the ultrafast dynamics of interionic interaction in imidazo
Ultrafast Photoinduced Electron Transfer between Tetramethylrhodamine and Guanosine in Aqueous Solut
Photophysical Properties of Atto655 Dye in the Presence of Guanosine and Tryptophan in Aqueous Solut
Thinner is better: ultrathin conducting oligoaniline film for gas microsensors with ultralow detecti
Transfer printing of metal nanoparticles with controllable dimensions, placement and reproducible SE
Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer matastasis
Direct Measurement of the Rates and Barriers on Forward and Reverse Diffusions of Intramolecular Col
Structural Heterogeneity in the Collision Complex between Organic Dyes and Tryptophan in Aqueous Sol
1A-Adrenergic Receptor Induces Activation of Extracellular Signal-Regulated Kinase 1/2 through Endoc
Measuring rapid enzymatic kinetics by electrochemical method in droplet-based microfluidic devices w
Interaction between Bacterial Outer Membrane Proteins and Periplasmic Quality Control Factors: A Kin
Thermo-chemically patterning of polymer film with tunable size reductions using metal-coated PDMS st
Processing matters: the in-situ fabrication of conducting-polymer microsensors enables ultra-low-lim
Domain Specific Folding Kinetics of Staphylococcal Nuclease Observed through Single-Molecule FRET in
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