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中文摘要：
经过近四年的研究工作, 圆满完成了研究计划，实现了预计各项科学目标，在分子诊断新原理、新方法、人类疾病相关标志物的识别与传感、细胞分析与表面受体检测、纳米功能化与微纳流控等方面取得了具有自主知识产权的系列研究成果，建立了有特色的分子诊断研究平台，并产生了国际影响。这些成果丰富和发展了分析化学基本原理和相关学科的内涵，为生命科学研究、临床诊断、卫生防疫与监督、食品安全和其它突发事件等的分析检测提供了新的技术与有力工具。研究成果发表与录用论文202篇（199篇为SCI刊物）(其中IF>3.0刊物139篇；>5.0刊物71篇)，申请发明专利21件，授权发明专利15件、实用新型专利1件。出版专著1部，合著专著1部，合编英文专著2部，为其它著作撰写中文专章2章、英文专章6章。参加国际会议77篇次，其中境外国际会议33次（邀请报告28次）。获教育部自然科学一等奖1项，省科技进步二等奖2项，其它科技奖4项，个人荣誉奖7项，3篇省优秀博士论文。
结论摘要：
英文主题词bioanalytical chemistry; molecular diagnosis; biosensing; microfluidic bioanalysis; cellar analysis
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Theoretical study of the interaction pattern and the binding affinity between procaine and DNA bases
Effect of enteral nutrition formula on fat absorption and serum free fatty acid profiles in rat with
Zirconia nanoparticles enhanced grafted collagen tri-helix scaffold for unmediated biosensing of hyd
Simultaneous determination of ethamsylate, tramadol and lidocaine in human urine by capillary electr
Novel coupling mechanism-based imaging approach to scanning electrochemical microscopy for probing t
Off-line form of the Michaelis-Menten equation for studying the reaction kinetics in a polymer micro
Microchannel-electrode alignment and separation parameters comparison in microchip capillary electro
Synthesis of metallic nanoparticles protected with N,N,N-trimethyl chitosan chloride via a relativel
Gold nanoparticles doped three-dimensional sol-gel matrix for amperometric human chorionic gonadotro
Simultaneous determination of psychotropic drugs in human urine by capillary electrophoresis with el
Flow-injection chemiluminescent immunoassay for alpha-fetoprotein based on epoxysilane modified glas
Electrogenerated chemiluminescence detection of amino acids based on precolumn derivatization couple
Multilayer membranes for glucose biosensing via layer-by-layer assembly of multiwall carbon nanotube
A gold nanoparticles/sol-gel composite architecture for encapsulation of immunoconjugate for reagent
Simultaneous electrochemiluminescence determination of sulpiride and tiapride by capillary electroph
A disposable electrochemical immunosensor for flow injection immunoassay of carcinoembryonic antigen
Electrochemical immunoassay of human chorionic gonadotrophin based on its immobilization in gold nan
Electrochemical study on synergistic effect of the blending of nano TiO2 and PLA polymer on the inte
Synergistic enhancement effect of magnetic nanoparticles on anticancer drug accumulation in cancer c
Noncovalent axial assembly of Picket-fence porphyrin on nitrogen-doped carbon nanotubes for highly e
Pretreatment-free fast ultraviolet detection of melamine in milk products with a disposable microflu
Determination, characterization and cytotoxicity on HELF of ZnO nanoparticles as ultraviolet screens
Simultaneous fabrication of through-hole porous membrane and nanotubes array in a single step anodiz
New anthracene–tetrathiafulvalene derivative-encapsulated SWNT nanocomposite and its application for
Quantum dot-functionalized poly(styrene-co-acrylic acid) microbeads: stepwise self-assembly, charact
Streptavidin-Functionalized Three-Dimensional Ordered Nanoporous Silica Film for Highly Efficient Ch
Dendritic silver/silicon dioxide nanocomposite modified electrodes for electrochemical sensing of hy
A chemiluminescent immunosensor based on antibody immobilized carboxylic resin beads coupled with mi
A channel-resolved approach coupled with magnet-captured technique for multianalyte chemiluminescent
Multipoint quantification of multimarker genes in peripheral blood and micrometastasis characteristi
Electrochemical study of the effect of functionalized nickel nanoparticles on cellular uptake of leu
Blends of TiO2 nanoparticles and poly (N-isopropylacrylamide)-co-polystyrene nanofibers as a means t
Channel-resolved multianalyte immunosensing system for flow-through chemiluminescent detection of al
A simple electrochemical method for the determination of hydroxyl free radicals without separation p
Electrochemical deposition and mechanism investigation of Prussian blue on graphic carbon paste elec
Surface electric field manipulation of the adsorption kinetics and biocatalytic properties of cytoch
Electrochemical determination of NDPhA via its electrocatalysis at porous Au electrode in room tempe
Improved separation efficiency of neurotransmitters on a native printed capillary electrophoresis mi
Electrochemically deposited nanocomposite film of CS-Fc/Au NPs/GOx for glucose biosensor application
Determination of nitrite based on its quenching effect on anodic electrochemiluminescence of CdSe qu
Highly sensitive amperometric biosensors for phenols based on polyaniline-ionic liquid-carbon nanofi
Direct Electrochemistry of Hemoglobin Immobilized on Colloidal Gold-Hydroxyapatite Nanocomposite for
Functionalization of Carbon Nanotubes with Water-Insoluble Porphyrin in Ionic Liquid: Direct Electro
Composition and Shape Control in the Construction of Functional Nickel Hexacyanoferrate Nanointerfac
One-step pyrolysis method for the synthesis of highly efficient 3D hollow carbon nanostructure suppo
Enhanced electrochemiluminescence efficiency of Ru(II) derivative covalently linked carbon nanotubes
A simple method for fabrication of sole composition nickel hexacyanoferrate modified electrode and i
Effect of surface microstructures on the separation efficiency of neurotransmitters on a direct-prin
Direct electrochemistry and electrocatalysis of hemoglobin on nanostructured gold colloid-silk fibro
Highly sensitive detection of daunorubicin based on carbon nanotubes–drug supramolecular interaction
Anodic electrochemiluminescence of CdSe nanoparticles coreacted with tertiary amine and halide induc
Addition of ethynylferrocene to transition-metal complexes containing a chelating 1,2-dicarba-closo-
Rapid identification and high sensitive detection of cancer cells on the gold nanoparticle interface
Study on the enhanced cellular uptake effect of daunorubicin on leukemia cells mediated via function
Application of the blending of PNIPAM- co -PS nanofibers with functionalized Au nanoparticles for th
Synergistic effect of functionalized nickel nanoparticles and quercetin on inhibition of the SMMC-77
Highly resolved separation and sensitive amperometric detection of amino acids with an assembled mic
Amperometric glucose sensor based on catalytic reduction of dissolved oxygen at soluble carbon nanof
Accelerated direct electrochemistry of hemoglobin based on hemoglobin-carbon nanotube (Hb-CNT) assem
The application of Fe3O4 nanoparticles in cancer research: A new strategy to inhibit drug resistance
Electrochemical DNA biosensor for the detection of short DNA species of Chronic Myelogenous Leukemia
Study of the nonenzymatic glucose sensor based on highly dispersed Pt nanoparticles supported on car
Functional multiwalled carbon nanotube nanocomposite with iron picket-fence porphyrin and its electr
Anodic electrochemiluminescence of CdTe quantum dots and its energy transfer for detection of catech
A disposable two-throughput electrochemical immunosensor chip for simultaneous multianalyte detennin
Enzyme-quantum dots architecture for highly sensitive electrochemiluminescence biosensing of oxidase
Detection of NADH and ethanol based on catalytic activity of soluble carbon nanofiber with low overp
A disposable multianalyte electrochemical immunosensor array for automated simultaneous determinatio
Sensitive reagentless electrochemical immunosensor based on an ormosil sol-gel membrane for human ch
An amperometric immunosensor for separation-free immunoassay of CA125 based on its covalent immobili
A disposable impedance sensor for electrochemical study and monitoring of adhesion and proliferation
One-step immobilization of glucose oxidase in a silica matrix on a Pt electrode by an electrochemica
Simultaneous electrochemiluminescence detection of anisodamine, atropine, and scopolamine in Flos da
Amperometric biosensor for hydrogen peroxide based on myoglobin doped multiwalled carbon nanotube en
Circulating tumor cells in perioperative esophageal cancer patients: Quantitative assay system and p
Highly sensitive flow injection detection of hydrogen peroxide with high throughput using a carbon n
A bio-inspired support of gold nanoparticles-chitosan nanocomposites gel for immobilization and elec
Reagentless biosensor for hydrogen peroxide based on immobilization of protein in zirconia nanoparti
Conductive mesocellular silica-carbon nanocomposite foams for immobilization, direct electrochemistr
Immobilization and electrochemical behavior of gold nanoparticles modified leukemia K562 cells and a
Hydrogen peroxide biosensor based on hemoglobin modified zirconia nanoparticles-grafted collagen mat
Highly efficient and of selective enrichment phosphopeptides using porous anodic alumina membrane fo
The synergistic effect of Prussian-Blue-grafted carbon nanotube/poly(4-vinylpyridine) composites for
Hydrogen bubble dynamic template synthesis of porous gold for nonenzymatic electrochemical detection
Superhydrophobicity of 3D porous copper films prepared by using the hydrogen bubble dynamic template
Amperometric sensor for ethanol based on one-step electropolymerization of thionine-carbon nanofiber
Al2O3/SnO2Co-nanoparticle modified grafted collagen for improving thermal stability and infrared emi
The effect of UV irradiation on the binding of anticancer drug doxorubicin to DNA in the presence of
DNA binding behavior of doxorubicin based on photovoltaic effect of nano titanium dioxide modified e
The enhancement effect of gold nanoparticles to facilitate the drug delivery and biomarker of drug-r
Magnetic controllable biorecognition process of doxorubicin detected by electrochemical contact angl
Amperometric detection of carbohydrates with a portable silicone/quartz capillary microchip by desig
Electrochemiluminescence sensors for scavengers of hydroxyl radical based on its annihilation in CdS
会议论文
Electrochemical contact angle study on biorecognition of doxorubicin with DNA based on the CdS nanop
Influence of nano titanium dioxide and UV irradition in the in vitro inhibition of multidrug resista
Specific Recognition of Cancer by Novel Ferrocene-Carborane Conjugates and Biocompatible Nanocomposi
Electrochemical assay of cell surface carbohydrates and electrochemiluminescence biosensing based on
The effect of UV irradiation on the binding of anticancer drug doxorubicin to DNA in the presence of
Electrochemical study of specific binding behaviour of the anticancer drug to DNA based on the blend
The synergistic effect of functional gold nanoparticles on the targeting drug delivery of cancer cel
Flow-Through Multianalyte Chemiluminescent Immunosensing System for Sequential Detection of Tumor Ma
High Sensitive Electrochemical Detection of Cancer Cells Based on PLA nanocomposite biosensing inter
Application of some biocompatible nanomaterials in target drug delivery and identification of cancer
Electrochemical Assay of Cell Surface Carbohydrates and Electrochemiluminescence Biosensing Based on
Application of some biocompatible nanomaterials in target drug delivery and identification of cancer
Electrochemiluminescence biosensing and bultiplex dynamic evaluation of cell surface glycome with el
Flexible microfluidic device coupled with fracture sampling for highly efficient detection of biomol
Coreactant enhanced anodic electrocherniluminescence of CdTe quantum dots at low potential for sensi
The Application of New Nanocomposites: Enhancement Effect of Polylactide Nanofibers/Nano TiO2 Blends
The Enhancement Effect of Functionalized Gold Nanoparticles on the Binding of Anticancer Drug to DNA
High Sensitive Electrochemical Detection of Cancer Cells Based on Gold Nanoparticle biosensing inter
SECM Probing the Electric Field Distribution at the End-Channel of a Microchip Capillary Electrophor
Magnetic-Induced Site-Specific Delivery of Organmetallic Carboranes Based on Fe3O4 NPs for BNCT, Int
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