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中文摘要：
由色素衍生的荧光探针、人工核酸酶及抗癌药物先导在生物医药领域发挥越来越重要的作用，其分子设计原理已成为精细有机化工中的关键科学问题。针对具有重要生物学意义的过渡或重金属离子(汞、铜、锌、镉)等客体，基于创新的非环多臂含氮受体及缺电性荧光团，发现并运用金属离子诱导去质子化的荧光传感及金属离子诱导变构正向协同作用荧光传感机理，设计其具有响应荧光波长位移大的、识别选择性极高的荧光探针及活体细胞传感器。创新获得数个由缺电性荧光团及多臂非硫非环开链组成的铜、锌及镉离子比例荧光传感器，发现并运用铜锌等诱导去质子传感机理，在水性溶液中或活体细胞中进行高选择高灵敏荧光信号传感。获得无金属依赖的萘酰亚胺核酸人工水解酶。发现核酸及拓扑酶靶向的能阻滞癌细胞周期或引发凋亡及抗多药耐受性的高活性硫稠环萘酰亚胺。设计长波长、强荧光苊并吡咯腈细胞乏氧标志荧光传感器。创造了抑制Bcl2 蛋白的癌细胞诱导凋亡剂新母体结构类型- - 硫杂苊并吡咯腈。
结论摘要：
英文主题词dye, fluorescence sensor, synthesized nuclease, leads of drugs, relationship of structure and effects
成果综合统计
期刊论文
会议论文
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期刊论文
A Rhodamine-Based Hg2+ Sensor with High Selectivity and Sensitivity in Aqueous Solution: A NS2-Conta
A colorimetric sensor for Cu2+ in aqueous solution based on metal ion-induced deprotonation: deproto
A Gold(I) Phosphine Complex Containing a Naphthalimide Ligand Functions as a TrxR Inhibiting Antipro
Selective and Sensitive Chromo- and Fluorogenic Dual Detection of Anionic Surfactants in Water Based
A red-shift colorimetric and fluorescent sensor for Cu2+ in aqueous solution: unsymmetrical 4,5-diam
Expression, purification and characterization of the chitinolytic beta-N-acetyl-D-hexosaminidase fro
Trace mercury (II) detection and separation in serum and water samples using a reusable bifunctional
Expression, purification and characterization of Gloydius shedaoensis venom gloshedobin as Hsp70 fus
Novel naphthalimide-amino acid conjugates with flexible leucine moiety as side chain: Design, synthe
Novel naphthalimide derivatives with near-infrared emission: synthesis via photochemical cycloaromat
Novel naphthalimide derivatives as potential apoptosis-inducing agents: Design, synthesis and biolog
Design, synthesis, and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters
Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavel
A series of polyamide receptor based PET fluorescent sensor molecules: Positively cooperative Hg2+ i
Detecting Hg2+ ions with an ICT fluorescent sensor molecule: Remarkable emission spectra shift and u
Exploiting the deprotonation mechanism for the design of ratiometric and colorimetric Zn2+ fluoresce
Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the prepara
A naphthalimide-calixarene as a two-faced and highly selective fluorescent chemosensor for Cu2+ or F
Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: Synthesis and biologic
Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescen
Multiple molecular logic functions and molecular calculations facilitated by surfactant's versatilit
Effects of anionic surfactant SDS on the photophysical properties of two fluorescent molecular senso
A Highly Sensitive and Selective OFF-ON Fluorescent Sensor for Cadmium in Aqueous Solution and Livin
Highly sensitive and selective Pd2+ sensor of naphthalimide derivative based on complexation with al
Highly selective fluorescent chemosensor with red shift for cysteine in buffer solution and its bioi
Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotox
Naphthalimide intercalators with chiral amino side chains: Effects of chirality on DNA binding, phot
Micelle-induced versatile performance of amphiphilic intramolecular charge-transfer fluorescent mole
会议论文
Inhibition of Topoisomerase or Bcl2 Protein in vitro and vivo: Electron-deficient Chromophores of Na
Fluorescent Molecular Sensor and Images for Metallic Cations with Biological Interests: Design, Synt
Green Chemistry of Pesticides and Dyes: Molecular Design and Structure- Property Relationship of Gre
Novel BTH Analogues as Elicitors for Secondary Metabolites in Cell Culture and Soil-borne Disease co
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