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中文摘要：
本项目拟以银、金、铜等金属为基础来构建有拉曼活性的基底层，通过功能材料合成技术对其形貌、尺度及结构进行调控，连续引入非导电薄膜和有拉曼活性的金属薄膜来设计、构建新型多层薄膜。利用表面增强拉曼光谱、电化学、红外光谱等技术来研究探针生物分子如蛋白质的特征结构、生物活性、界面取向及表面催化反应机理等，深入理解蛋白质结构与功能的关系，构建光电生物传感器件。采用稳态或时间分辨表面增强共振拉曼光谱-电化学联用技术来研究血红素类蛋白质在该体系中的电子传递过程，揭示电子传递机理。考察非导电薄膜和金属薄膜的介电性能及其厚度对探针生物分子拉曼信号的影响，实现光电信号的远程调控。建立表面增强拉曼散射理论模型，探讨非导电薄膜和金属薄膜间拉曼信号的增强机制。利用该体系构建宽电位、宽光谱的新型光电生物传感器件，并拓展其在免疫分析、生物分析、环境监测及药物与蛋白质的相互作用等领域的应用研究。
英文摘要：
SERS；Small molecules controlled Synthesis；Hierarchical structures；Noble metals；
结论摘要：
经过四年的努力，本研究工作达到了预期目标，利用生物小分子(天冬门酰胺、精氨酸、胞嘧啶、谷氨酸、氨基葡萄糖)、有机小分子(乙二胺、N-甲基咪唑、尿素、三聚氰胺、咖啡因、尿囊素、对氨基吡啶、二羟丙茶碱、二甲双胍)、无机离子(Fe3+、NO2-、I-) 等调控，结合电沉积和湿化学等合成技术，合成了具有多级微纳结构的贵金属纳米材料，构建了可控制备高拉曼活性的基底材料，成功构筑Au-AHMT-formaldehyde、Au-MPY–Pb2+、AuPt-MPY-glucose、Au-4-MBA和Au-ATP多层表面增强拉曼活性器件，实现了的表面增强拉曼（SERS）的远程调控，可以用于甲醛、葡萄糖Pb2+、Pb2+以及一些巯基分子的SERS检测。 由于Au、Ag 、Pd等贵金属材料有良好的拉曼增强效应，我们开展了多级微纳米结构的一元、二元以及多元合金材料的合成方法学的研究。在电沉积、一步湿化学合成、水热合成、溶剂热合成等条件下，探讨了小分子化合物对纳米材料的形貌、SERS光谱性能和光电催化性能的影响，并对其生长机理进行了研究。实验发现氨基（生物）分子对贵金属的可控合成具有良好的调控作用，进而构建多个光电生物传感器件。在该基金的资助下，目前累计发表论文112篇，其中SCI论文109篇，影响因子大于6.0的30篇(2篇Biosens. Bioelectron.；3篇ACS Appl. Mater. Interfaces；3篇Nanoscale；9篇J. Mater. Chem. A；13篇J. Power Sources)，J. Mater. Chem. A前封面论文1篇；J. Mater. Chem. C后封面论文1篇。申报国家发明专利5个，已授权3个；培养研究生来18名，其中8名同学获国家奖学金。
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期刊论文
Melamine assisted one-pot synthesis of Au nanoflowers and their catalytic activity towards p-nitroph
(D)-Penicillamine-Assisted Self-Assembly of Hierarchical PbS Microstars with Octa-Symmetric-Dendriti
Caffeine-assisted facile synthesis of platinum@palladium core-shell nanoparticles supported on reduc
Novel phenol biosensor based on laccase immobilized on reduced graphene oxide supported palladium-co
Surfactant-free synthesis of reduced graphene oxide supported porous PtAu alloyed nanoflowers with i
Facile large-scale synthesis of Au-Pt alloyed nanowire networks as efficient electrocatalysts for me
Facile synthesis of porous bimetallic alloyed PdAg nanoflowers supported on reduced graphene oxide f
Facile synthesis of N, S-codoped fluorescent carbon nanodots for fluorescent resonance energy transf
Nonenzymatic amperometric sensing of glucose using a glassy carbon electrode modified with a nanocom
Simple electrodeposition of hierarchical gold-platinum nanothorns and their applications in electroc
Green and facile synthesis of l-carnosine protected fluorescent gold nanoclusters for cellular imagi
One-pot synthesis of platinum3cobalt nanoflowers with enhanced oxygen reduction and methanol oxidati
Facile synthesis of platinum-ruthenium nanodendrites supported on reduced graphene oxide with enhanc
Simple one-pot synthesis of platinum-palladium nanoflowers with enhanced catalytic activity and meth
Facile synthesis of MnO2-Ag hollow microspheres with sheet-like subunits and their catalytic propert
One-step, seedless wet-chemical synthesis of gold@palladium nanoflowers supported on reduced graphen
Urea assisted electrochemical synthesis of flower-like platinum arrays with high electrocatalytic ac
Cytosine-assisted synthesis of gold nanochains and gold nanoflowers for the construction of a microp
Facile synthesis of uniform Pt nanoparticles on polydopamine-reduced graphene oxide and their electr
Gelatin-assisted hydrothermal synthesis of single crystalline zinc oxide nanostars and their photoca
Amperometric glucose sensor based on enhanced catalytic reduction of oxygen using glucose oxidase ad
Simple and sensitive detection method for diprophylline using glutathione-capped CdTe quantum dots a
Polyinosinic acid-stabilized fluorescent silver nanoclusters for sensitive detection of biological t
Green synthesis of porous flower-like palladium with high electrocatalytic activity towards methanol
Facile synthesis of Pd nanochains with enhanced electrocatalytic performance for formic acid oxidati
Solvent-free synthesis of sulfur- and nitrogen-co-doped fluorescent carbon nanoparticles from glutat
One-step green synthesis of fluorescent bimetallic Au/Ag nanoclusters for temperature sensing and in
Green synthesis of peptide-templated fluorescent copper nanoclusters for temperature sensing and cel
Simultaneous determination of trace levels of lead(II) and copper(II) by square wave stripping volta
Facile synthesis of monodisperse porous Cu2O nanospheres on reduced graphene oxide for non-enzymatic
Facile and controlled electrochemical route to three-dimensional hierarchical dendritic gold nanostr
D-penicillamine assisted hydrothermal synthesis of Bi2S3 nanoflowers and their electrochemical appli
N-methylimidazole-assisted electrodeposition of Au porous textile-like sheet arrays and its applicat
Simultaneous determination of dopamine and uric acid in the presence of ascorbic acid using Pt nanop
Sensitive detection of mercury (II) ion using water-soluble captopril-stabilized fluorescent gold na
Control growth of single crystalline ZnO nanorod arrays and nanoflowers with enhanced photocatalytic
Facile synthesis of hierarchical dendritic PtPd nanogarlands supported on reduced graphene oxide wit
One-pot synthesis of reduced graphene oxide supported hollow Ag@Pt core-shell nanospheres with enhan
A single-step route for large-scale synthesis of core-shell palladium@platinum dendritic nanocrystal
One-step wet-chemical synthesis of gold nanoflower chains as highly active surface-enhanced Raman sc
One-step melamine-assisted synthesis of graphene-supported AuPt@Au nanocrystals for enhanced catalyt
Cu(II)@Luviset clear as recyclable catalyst for the formation of C-C bond in homo-coupling of termin
Eco-friendly and rapid microwave synthesis of green fluorescent graphitic carbon nitride quantum dot
Simple synthesis of bimetallic AuPd dendritic alloyed nanocrystals with enhanced electrocatalytic pe
One-pot wet-chemical synthesis of PtPd@Pt nanocrystals supported on reduced graphene oxide with high
Bio-directed one-pot synthesis of Pt-Pd alloyed nanoflowers supported on reduced graphene oxide with
Aminoorotic acid directed synthesis of graphene-supported AuPt nanocrystals with enhanced electrocat
One-pot solvothermal synthesis of bimetallic yolk-shell Ni@PtNi nanocrystals supported on reduced gr
Electrochemical sensor for nitrite using a glassy carbon electrode modified with gold-copper nanocha
Facile synthesis of oxygen and sulfur co-doped graphitic carbon nitride fluorescent quantum dots and
Simple polyol synthesis of porous coral-like palladium-silver alloy nanostructures with enhanced ele
Facile preparation of reduced graphene oxide supported PtNi alloyed nanosnowflakes with high catalyt
Enhanced catalytic performance of Pd-Pt nanodendrites for ligand-free Suzuki cross-coupling reaction
Facile synthesis of three-dimensional Pt-Pd alloyed multipods with enhanced electrocatalytic activit
Facile synthesis of platinum-gold alloyed string-bead nanochain networks with the assistance of alla
A simple and controlled electrochemical deposition route to urchin-like Pd nanoparticles with enhanc
Electrochemical determination of bisphenol A with a glassy carbon electrode modified with gold nanod
Facile synthesis of porous Pt–Pd nanospheres supported on reduced graphene oxide nanosheets for enha
Sensitive and selective colorimetric detection of cadmium(II) using gold nanoparticles modified with
A study on the direct electrochemistry and electrocatalysis of microperoxidase-11 immobilized on a p
Hierarchical wheat-like Au–Pd heterostructures with enhanced catalytic activity toward methanol elec
A facile general strategy for synthesis of palladium-based bimetallic alloyed nanodendrites with enh
Monodisperse Au-Pd bimetallic alloyed nanoparticles supported on reduced graphene oxide with enhance
Branched platinum-on-palladium bimetallic heteronanostructures supported on reduced graphene oxide f
A model of interface-related enhancement based on the contrast between Co3O4 sphere and cube for ele
Simple synthesis of hollow Pt-Pd nanospheres supported on reduced graphene oxide for enhanced methan
Facile synthesis of PdPt@Pt nanorings supported on reduced graphene oxide with enhanced electrocatal
Simple synthesis of platinum-palladium nanoflowers on reduced graphene oxide and their enhanced cata
Rapid room-temperature synthesis of Pd nanodendrites on reduced graphene oxide for catalytic oxidati
A simple one-pot strategy to platinum-palladium@palladium core-shell nanostructures with high electr
Facile synthesis of reduced graphene oxide supported PtAg nanoflowers and their enhanced electrocata
Ionic liquid crystal-assisted synthesis of PtAg nanoflowers on reduced graphene oxide and their enha
Shaped-controlled electrosynthesis of gold nanodendrites for highly selective and sensitive SERS det
Green synthesis of core-shell gold-palladium@palladium nanocrystals dispersed on graphene with enhan
Facile synthesis of bimetallic alloyed Pt-Pd nanocubes on reduced graphene oxide with enhanced eletr
L-Arginine-assisted electrochemical fabrication of hierarchical gold dendrites with improved electro
Simple wet-chemical synthesis of alloyed PdAu nanochain networks with improved electrocatalytic prop
One-pot synthesis of platinum-palladium-cobalt alloyed nanoflowers with enhanced electrocatalytic ac
Biomolecule-assisted synthesis of porous PtPd alloyed nanoflowers supported on reduced graphene oxid
A general strategy for the facile synthesis of AuM (M = Pt/Pd) alloyed flowerlike-assembly nanochain
Simple synthesis of worm-like Au-Pd nanostructures supported on reduced graphene oxide for highly se
One-pot wet-chemical co-reduction synthesis of bimetallic gold platinum nanochains supported on redu
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