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中文摘要：
针对目前蛋白质组和多肽组学研究存在的主要技术瓶颈和国内在蛋白质修饰谱、多肽组学研究尚处于起步阶段的实际，结合申请者在生物分离分析新技术和新材料科研工作中所形成的基础和积累，开展了蛋白质和多肽的高选择性富集技术和方法、高通量蛋白质组分析方法方面的创新性研究，有效提高了我国在蛋白质修饰谱、多肽组学等方面的研究水平，形成一个具有国际一流水平的蛋白质组和多肽组学新技术新方法的研究团队。相关研究成果发表学术论文70篇。主要研究成果包括富集内源性多肽、修饰蛋白质和修饰肽的新方法，蛋白质组样品的自动进样和分离系统，微分离分析柱技术及其联用装置的接口技术；以及相关新技术在生物样品蛋白质组和多肽组学分析中的应用等。这些技术和方法的突破为蛋白质组学和多肽组学的研究、重大疾病的早期诊断以及药物先导物的高通量筛选等生命科学中的重大研究领域提供新的技术体系和方法。
结论摘要：
英文主题词Proteomics; peptidomics; chromatographic separation; mass spectrometry;sample pretreatment
成果综合统计
期刊论文
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期刊论文
Polyhedral Oligomeric Silsesquioxane as a Cross-linker for Preparation of Inorganic-Organic Hybrid M
Combined Comparative and Chemical Proteomics on the Mechanisms of levo-Tetrahydropalmatine-Induced A
The synthesis of chloropropyl-functionalized silica hybrid monolithic column with modification of N,
Identification of Angiotensin I-Converting Enzyme Inhibitors in Peptides Mixture of Hydrolyzed Red D
Fractionation of phosphopeptides on strong anion-exchange capillary trap column for large-scale phos
Classification Filtering Strategy to Improve the Coverage and Sensitivity of Phosphoproteome Analysi
Reversed-Phase-Reversed-Phase Liquid Chromatography Approach with High Orthogonality for Multidimens
Coupling Strong Anion-Exchange Monolithic Capillary with MALDI-TOF MS for Sensitive Detection of Pho
Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple st
P-Glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human L
Vinyl functionalized silica hybrid monolith-based trypsin microreactor for on line digestion and sep
Preparation of Perphenylcarbamoylated beta-Cyclodextrin-silica Hybrid Monolithic Column with "One-Po
Development of Glycoprotein Capture-Based Label-Free Method for the High-throughput Screening of Dif
The highly selective capture of phosphopeptides by zirconium phosphonate-modified magnetic nanoparti
Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosph
Online multidimensional separation with biphasic monolithic capillary column for shotgun proteome an
Profiling of Endogenous Serum Phosphorylated Peptides by Titanium (IV) Immobilized Mesoporous Silica
Selective enrichment of endogenous peptides by chemically modified porous nanoparticles for peptidom
Phosphonic Acid Functionalized Periodic Mesoporous Organosilicas and Their Potential Applications in
Selective on-line serum peptide extraction and multidimensional separation by coupling a restricted-
Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposom
Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by t
Comprehensive and Reliable Phosphorylation Site Mapping of Individual Phosphoproteins by Combination
Glycoproteomics Analysis of Human Liver Tissue by Combination of Multiple Enzyme Digestion and Hydra
Integration of monolithic frit into the particulate capillary (IMFPC) column in shotgun proteome ana
Preparation of monodisperse immobilized Ti4+ affinity chromatography microspheres for specific enric
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