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中文摘要：
申请者立足国内，主要工作1、以微小模型等揭示2型糖尿病双重缺陷作用机制，证实在糖尿病前期已有血管并发症；2、在基因水平诊断18 种遗传性内分泌代谢病，发现25种基因突变类型，11种在国际上未见报道，并首次报道症状轻微的 17-OHD这一新临床类型；3、首先发现pak3参与神经内分泌肿瘤发生，首次证明POMC启动子区域低甲基化是其异常过度表达原因，为研究其他激素异位分泌机制及治疗方法奠定基础。发表包括本领域权威杂志JCEM（2篇;IF:6.02 ）在内的SCI论文近30篇，引证达370余次。主编专著2部。先后获973课题及3项国家自然基金等，入选国家新世纪百千万人才工程国家级人选、国务院特殊津贴和上海市领军人才、市优秀学科带头人等，获上海科技进步1等奖、中华医学科技2等奖等。申请者将在以往工作基础上，研究ACTH依赖性Cushing综合征的发病机制、治疗方法，以期在理论和临床上有所突破。
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期刊论文
Ablation of steroid receptor coactivator-3 in mice impairs adipogenesis and enhances energy expendit
The novel compound heterozygous mutations, V434del and W666X, in WFS1 gene causing the Wolfram syndr
Different association of circulating levels of adipocyte and epidermal fatty acid-binding proteins w
Seven Novel DAX1 Mutations with Loss of Function Identified in Chinese Patients with Congenital Adre
Impact of the metabolic syndrome and its individual components on risk andseverity of coronary heart
Insulin sensitivity and first-phase insulin secretion in obese Chinese with hyperglycemia in 30 and/
GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and ex
Low-Grade Albuminuria Is Associated with Carotid Intima-Media Thickness in Chinese Type 2 Diabetic P
Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a C
Association between alcohol consumption and metabolic syndrome in 19,215 middle-aged and elderly Chi
Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly
Brown Adipose Tissue in humans is Activated by Elevated Plasma Catecholamines Levels and is Inversel
G protein-coupled receptor 48 upregulates estrogen receptor α expression via cAMP/PKA signaling in t
Gene expression profiles of thymic neuroendocrine tumors(carcinoids) with ectopic ACTH syndrome reve
Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injur
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