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中文摘要：
木豆[ Cajanus cajan (L. )Millsp ]是豆科木豆属一年生或多年生灌木，分布地区广泛，在国内外民间用木豆叶可治疗炎症、疮痈肿痛和水痘等与病毒有关的疾病。项目组前期研究发现木豆叶提取物具有较强的抗HSV活性，并结合民间用药基础，本项目拟在已有研究成果基础上，用RC-37接种HSV-1和HSV-2病毒进行细胞毒和抗HSV活性分析，以活性筛选为指导，对木豆叶活性物质进行提取分离、纯化和结构鉴定，筛选出木豆叶抗HSV的活性部位和活性成分，并通过宿主细胞pH、膜电位等生理信号变化、病毒DNA 复制和重组的中间体构象、宿主细胞周期和凋亡改变以及病毒mRNA复制含量的变化，在细胞水平和分子水平探讨木豆叶活性成分抗HSV的作用机制。本项目对进一步促进我国木豆资源的深度开发和利用提供科学依据，对研制木豆抗HSV-1型口唇、角膜疱疹和抗HSV-2型生殖器疱疹病毒的外用新药提供科学基础。
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期刊论文
Variation in contents of phenolic compounds during growth and post-harvest storage of pigeon pea see
Optimization of microwave-assisted extraction of cajaninstilbene acid and pinostrobin from pigeonpea
Activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force m
Plasma pharmacokinetics and tissue distribution study of cajaninstilbene acid in rats by liquid chro
Chemical composition of the SFE-CO2 extracts from Cajanus cajan (L.) Huth and their antimicrobial ac
In Vitro Antioxidant Properties, DNA Damage Protective Activity, and Xanthine Oxidase Inhibitory Eff
Comparative study on the antiherpetic activity of aqueous and ethanolic extracts derived from Cajanu
Enzyme assisted extraction of luteolin and apigenin from pigeonpea [Cajanus Cajan (L.) Millsp.] leav
Preliminary enrichment and separation of genistein and apigenin from extracts of pigeon pea roots by
Determination and quantification of active phenolic compounds in pigeon pea leaves and its medicinal
Ethanol modified supercritical fluid extraction and antioxidant activity of cajaninstilbene acid and
Antioxidant activities of extracts and main components of pigeonpea [Cajanus cajan (L.) Millsp.] lea
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