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结论摘要：
本项目发展了多种生物样品中汞和硒的种态分析及定量分析方法，包括HPLC-ICP-MS、ID-ICP-MS及HPLC-ID-ICP-MS等，解决了ICP-MS分析汞时的记忆效应问题。在此基础上，开展了汞在母子体间的分布与毒性差异、汞污染地区生物样品中汞和硒的化学种态研究，尝试采用补硒的方法防治汞的危害并评价了稀土元素的神经毒性，主要结果如下 1）经早期胚胎发育期和出生后哺乳期接触低剂量汞暴露后，在母子鼠脑区中总汞、无机汞和甲基汞及汞结合蛋白的分布上均有明显的差异，提示汞在母子体中的代谢和毒性机制不同；2）建立了长期汞暴露人群DNA损伤的生物标志物－8-羟基-2'-脱氧鸟嘌呤核苷；4）长期汞暴露人群通过硒干预，可以促进体内汞的排出，提高其机体抗氧化能力，修复汞暴露带来的肾损伤及DNA氧化损伤，从而提高了长期汞暴露人群的健康水平；3）长期低剂量稀土暴露可引起的学习记忆能力损伤，这可能与生物体内微量元素失衡、钙稳态被破坏及随后引发的氧化损伤相关，体现为一种多途径、多步骤、间接的作用机制。本项目的工作在深入探讨汞和稀土毒理机制的同时，为汞中毒的预防与治疗和稀土的合理使用提供了科学依据。
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Spatial distribution of elements in the brain of rats measured by synchrotron radiation X-ray fluore
Quantitative analysis of iron in protein bands existing in polyacrylamide gel matrix with synchrotro
Concentrations and XAFS speciation in situ of mercury in hair from populations in Wanshan mercury mi
Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercur
Element distribution in the brain sections of rats measured by synchrotron radiation X-ray fluoresce
Mercury and trace element distribution in organic tissues and regional brain of fetal rat after in u
Translocation of inhaled TiO2 nanoparticles along olfactory nervous system to brain studied by synch
The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated end
Element distribution in the brain of rats exposed to lanthanum measured by synchrotron radiation X-r
Neurotoxicity of Low-Dose Repeatedly Intranasal Instillation of Nano- and Submicron-Sized Ferric Oxi
Quantitative analysis of proteins via sulfur determination by HPLC coupled to isotope dilution ICP-M
Effect of Iodine Supplement on Iodine Status and 5'-Deiodinase Activity in the Brain of Neonatal Rat
Mercury in human hair and blood samples from people living in Wanshan mercury mine area, Guizhou, Ch
Preliminary study of selenium and mercury distribution in some porcine tissues and their subcellular
Study on distribution and location of selenium and other elements in different mitochondrial compart
The effects of Meso 2, 3-dimercaptosuccinic acid and Olipomeric Procyanidins on acute lead neurotoxi
Analysis of mercury-containing protein fractions in brain cytosol of the maternal and infant rats af
Increased Oxidative DNA Damage, as Assessed by Urinary 8-Hydroxy-2'-Deoxyguanosine Concentrations, a
Preliminary study on roles of oxidative stress in human hepatocellular carcinoma and adjacent normal
Ytterbium and trace element distribution in brain and organic tissues of offspring rats after prenat
Tissue Contents and Intracellular Distribution of Selenium and Iodine in Human Tissues Studied by Ne
The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational
Scalp hair as a biomarker in environmental and occupational mercury exposed populations: Suitable or
Simultaneous speciation of selenium and mercury in human urine samples from long-term mercury-expose
Isotopic tracer studies on the metabolism and functional roles of mineral elements in institute of h
SRXRF study of trace elements in hippocampus of pup rats after prenatal and postnatal exposure to lo
会议论文
Speciation of Selenium and Other Trace Elements in Hepatocellular Carcinoma by INAA, HPLC-ICP-MS and
Effects of Lanthanum on Across Membrane Transport of Mineral Elements in Single Cells of Chara coral
Development of ultrasound-assisted extraction for mercury speciation studies in biological samples u
SRXRF study of trace elements in hippocampus of pup rats after prenatal and postnatal exposure to lo
Study on the mercury-containing proteins in dam and pup rats by stable isotopic tracer technique and
Methods to remove external mercury contamination in human scalp hair samples from Wanshan mercury mi
Simultaneous determination of mercury and selenium species in urine from long-term mercury exposed p
Study of Loss and Recuperation of Inorganic Elements of Osteoporotic Rat Bone with Nuclear Analytica
Detection of mercury-, arsenic-, and selenium-containing proteins in fish liver from a mercury pollu
Bio-distribution of copper nanoparticles in "model" organism, caenorhabditis elegans, mapped with mi
Speciation of Trace Elements in Biological Samples by Nuclear Analytical and Related Techniques Coup
Determination of Mercury Species in Biological Samples by Inductively Coupled Plasma Mass Spectromet
Selenium and mercury in human samples from long-term mercury-exposed populations with supplementatio
Scalp hair as a biomarker in environmental and occupational mercury exposed populations: Suitable or
Isotope techniques for quantitative study of mercury-containing proteins in brain of maternal and in
Development of a Mild Mercaptoethanol Extraction Method for Determination of Mercury Species in Biol
Nicotine attenuates β-amyloid- induced neurotoxicity in APPV717I transgenic mice, APPsw over express
Modern nuclear analytical techniques and their innovative applications in nanotechnology, biology, i
Simultaneous speciation analysis of selenium and mercury in human urine samples from long-term mercu
Quantitative analysis of mercury-binding proteins in brain cytosol of the rats exposed to low-dose m
Concentrations and XAFS speciation in situ of mercury in hair from populations in Wanshan mercury mi
Mercury and selenium containing proteins in serum of dam and pup rats after prenatal exposure to low
Neutron Activation Analysis of Trace Elements in Organics and Regional Brain of Pup Rat After In Ute
Element distribution in the brain of rats exposed to lanthanum measured by synchrotron radiation X-r
张智勇的项目